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Protein-coding gene in humans
Beta-1,4 N-acetylgalactosaminyltransferase 1 is an enzyme that in humans is encoded by the B4GALNT1 gene .[ 5] [ 6]
GM2 and GD2 gangliosides are sialic acid-containing glycosphingolipids . GalNAc-T is the enzyme involved in the biosynthesis of G(M2) and G(D2) glycosphingolipids. GalNAc-T catalyzes the transfer of GalNAc into G(M3) and G(D3) by a beta-1,4 linkage, resulting in the synthesis of G(M2) and G(D2), respectively.[ 6]
^ a b c GRCh38: Ensembl release 89: ENSG00000135454 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006731 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Nagata Y, Yamashiro S, Yodoi J, Lloyd KO, Shiku H, Furukawa K (Jul 1992). "Expression cloning of beta 1,4 N-acetylgalactosaminyltransferase cDNAs that determine the expression of GM2 and GD2 gangliosides" . J Biol Chem . 267 (17): 12082–9. doi :10.1016/S0021-9258(19)49809-8 PMID 1601877 . ^ a b "Entrez Gene: B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1" .
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