Blood–brain barrier disruption
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Blood–brain barrier disruption is the surgical process whereby drugs are used to create openings between cells in the blood–brain barrier.[1]
Purpose
[edit]The blood–brain barrier (BBB) is protected by a network of blood vessels and tissue that shields it from harmful substances. This protection also stops anti-cancer drugs from getting to the brain. To treat brain tumours and other brain related diseases,[2][3] blood–brain barrier disruption is needed for the anti-cancer drugs to be infused into an artery that goes to the brain.[1]
Effects
[edit]Studies have shown that blood–brain barrier disruption can cause diseases in the central nervous system.[4][5]
References
[edit]- ^ a b "Definition of blood–brain barrier disruption". www.cancer.gov. 2011-02-02. Retrieved 2023-02-09.
- ^ Tomkins, O.; Shelef, I.; Kaizerman, I.; Eliushin, A.; Afawi, Z.; Misk, A.; Gidon, M.; Cohen, A.; Zumsteg, D.; Friedman, A. (2008-07-01). "Blood–brain barrier disruption in post-traumatic epilepsy". Journal of Neurology, Neurosurgery & Psychiatry. 79 (7): 774–777. doi:10.1136/jnnp.2007.126425. ISSN 0022-3050. PMID 17991703. S2CID 29504371.
- ^ "Blood-Brain Barrier Disruption (BBBD) for Liquid Biopsy in Subjects With GlioBlastoma Brain Tumors". ClinicalTrials.gov. Retrieved 2024-08-06.
- ^ Segura-Collar, Berta; Mata-Martínez, Pablo; Hernández-Laín, Aurelio; Sánchez-Gómez, Pilar; Gargini, Ricardo (June 2022). "Blood–brain barrier Disruption: A Common Driver of Central Nervous System Diseases". The Neuroscientist. 28 (3): 222–237. doi:10.1177/1073858420985838. hdl:20.500.12105/11670. ISSN 1089-4098. PMID 33446074. S2CID 231611519.
- ^ Okada, Takeshi; Suzuki, Hidenori; Travis, Zachary D.; Zhang, John H. (2020). "The Stroke-Induced Blood–brain barrier Disruption: Current Progress of Inspection Technique, Mechanism, and Therapeutic Target". Current Neuropharmacology. 18 (12): 1187–1212. doi:10.2174/1570159X18666200528143301. PMC 7770643. PMID 32484111.