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Glycoprotein hormones, alpha polypeptide

From Wikipedia, the free encyclopedia
CGA
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCGA, CG-ALPHA, FSHA, GPHA1, GPHa, HCG, LHA, TSHA, Chorionic gonadotropin alpha, glycoprotein hormones, alpha polypeptide, Alpha subunit of glycoprotein hormones, GPA1
External IDsOMIM: 118850; MGI: 88390; HomoloGene: 587; GeneCards: CGA; OMA:CGA - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001252383
NM_000735

NM_009889

RefSeq (protein)

NP_000726
NP_001239312

NP_034019

Location (UCSC)Chr 6: 87.09 – 87.1 MbChr 4: 34.89 – 34.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glycoprotein hormones, alpha polypeptide is a protein that in humans is encoded by the CGA gene.[5]

The gonadotropin hormones, human chorionic gonadotropin (hCG), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and thyroid-stimulating hormone (TSH) are heterodimers consisting of alpha and beta subunits (also called chains) that are associated non-covalently. The alpha subunits of these four human glycoprotein hormones are identical; however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135346Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028298Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Fiddes JC, Goodman HM (Oct 1982). "The gene encoding the common alpha subunit of the four human glycoprotein hormones". Journal of Molecular and Applied Genetics. 1 (1): 3–18. PMID 6286817.
  6. ^ "Entrez Gene: CGA glycoprotein hormones, alpha polypeptide".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.