The album represents a whole new direction for the singer. Her previous album, Prelude, a 'best of' album, had ended her classical career; Tissues and Issues is her first ever pop album.
The first single to be taken from the album, "Crazy Chick", released shortly before the album itself, reached number two on the UK Singles Chart. "Call My Name", the second single, reached number ten in October 2005. "Even God", the third single, debuted in the Top 20 in early December 2005. The fourth single, "Moodswings (To Come at Me like That)", was released on 27 February 2006, and peaked at number fourteen on the UK charts.
Tissues and Issues is Charlotte Church's second and final album with Sony Music UK.