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Steve Horvath

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Steve Horvath
Horvath presenting a talk in 2015
Born
Frankfurt, Germany
OccupationProfessor of Human Genetics & Biostatistics
Known forDeveloping the epigenetic clock (Horvath clock) and weighted correlation network analysis
Academic background
Alma materTechnische Universität Berlin
(BS)
University of North Carolina, Chapel Hill
(PhD)
Harvard School of Public Health
(Sc.D)
Doctoral advisorRobert Brown Gardner
Nan Laird
Academic work
InstitutionsUCLA
Altos Labs

Steve Horvath is a German–American aging researcher, geneticist, and biostatistician. He is a professor at the University of California, Los Angeles known for developing the Horvath aging clock, which is a highly accurate molecular biomarker of aging, and for developing weighted correlation network analysis. His work on the genomic biomarkers of aging, the aging process, and many age related diseases/conditions has earned him several research awards. Horvath is a principal investigator at the anti-aging startup Altos Labs[1] and co-founder of nonprofit Clock Foundation.[2]

Background

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Horvath was born 1967 in Frankfurt, Germany; as the family name Horvath indicates, he is of Hungarian ancestry. He received his Diplom in Mathematics and Physics at Technische Universität Berlin, graduating in 1989.[3][4] He received his Ph.D. in mathematics at the UNC Chapel Hill in 1995 and his Sc.D. in biostatistics at Harvard in 2000.[4] In 2000, Horvath joined the faculty of the University of California, Los Angeles, where he is a professor of human genetics at the David Geffen School of Medicine at UCLA and of biostatistics at the UCLA Fielding School of Public Health.[3]

Work on the epigenetic clock

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Horvath's development of the DNA methylation based age estimation method known as epigenetic clock was featured in Nature magazine.[3] In 2011, Horvath co-authored the first article that described an age estimation method based on DNA methylation levels from saliva.[5] In 2013 Horvath published a single author article on a multi-tissue age estimation method that applies to all nucleated cells, tissues, and organs.[6][3] This discovery, known as the Horvath clock, was unexpected because cell types differ in terms of their DNA methylation patterns and age related DNA methylation changes tend to be tissue specific.[3] In his article, he demonstrated that estimated age, also referred to as DNA methylation age, has the following properties: it is close to zero for embryonic and induced pluripotent stem cells, it correlates with cell passage number; it gives rise to a highly heritable measure of age acceleration; and it is applicable to chimpanzees.[6] Since the Horvath clock allows one to contrast the ages of different tissues from the same individuals, it can be used to identify tissues that show evidence of increased or decreased age.[7]

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Horvath co-authored the first articles demonstrating that DNA methylation age predicts life-expectancy [8][9][10] and is positively associated with obesity,[11] HIV infection,[12] Alzheimer's disease,[13] cognitive decline,[14] Parkinson's disease,[15] Huntington's disease,[16] early menopause,[17] and Werner syndrome.[18]

Genetics of aging

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Horvath published the first article demonstrating that trisomy 21 (Down syndrome) is associated with strong epigenetic age acceleration effects in both blood and brain tissue.[19] Using genome-wide association studies, Horvath's team identified the first genetic markers (SNPs) that exhibit genome-wide significant associations with epigenetic aging rates[20][21] – in particular, the first genome-wide significant genetic loci associated with epigenetic aging rates in blood notably the telomerase reverse transcriptase gene (TERT) locus.[22]

As part of this work, his team uncovered a paradoxical relationship: genetic variants associated with longer leukocyte telomere length in the TERT gene paradoxically confer higher epigenetic age acceleration in blood.[22]

Work in biodemography

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Horvath proposed that slower epigenetic aging rates could explain the mortality advantage of women and the Hispanic mortality paradox.[23]

Lifestyle factors and nutrition

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Horvath published the first large scale study of the effect of lifestyle factors on epigenetic aging rates.[24]

These cross sectional of epigenetic aging rates in blood confirm the conventional wisdom regarding the benefits of education, eating a high plant diet with lean meats, moderate alcohol consumption, physical activity and the risks associated with metabolic syndrome.

Epigenetic clock theory of aging

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Horvath and Raj proposed an epigenetic clock theory of aging[25] which views biological aging as an unintended consequence of both developmental programs and maintenance program, the molecular footprints of which give rise to DNA methylation age estimators. DNAm age is viewed as a proximal readout of a collection of innate ageing processes that conspire with other, independent root causes of aging, to the detriment of tissue function.[25]

Weighted correlation network analysis

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Horvath and members of his lab developed a widely used systems biological data mining technique known as weighted correlation network analysis.[26][27][28] He published a book on weighted network analysis and genomic applications.[29]

Awards and honors

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Horvath has won several awards for his work on the epigenetic clock.

  • 2017 Allen Distinguished Investigator award for clock studies in vertebrates [30]
  • 2019 Open Philanthropy Project award for mechanistic studies of the epigenetic clock [31]
  • 2019 Schober Award for outstanding and innovative research in the field of ageing [32]
  • 2022 Nathan W. Shock Award [33]
  • 2022 Fellow of the American Statistical Association[34]
  • 2023 WNAR Outstanding Impact Award for Epigenetic Clocks and Weighted Correlation Network Analysis [35]

References

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  1. ^ "Meet Altos Labs, Silicon Valley's latest wild bet on living forever". 4 September 2021.
  2. ^ "About the Clock Foundation". 12 October 2023.
  3. ^ a b c d e Gibbs, WT (2014). "Biomarkers and ageing: The clock-watcher". Nature. 508 (7495): 168–170. Bibcode:2014Natur.508..168G. doi:10.1038/508168a. PMID 24717494.
  4. ^ a b "About the universities". University of California Los Angeles. Retrieved 20 August 2020.
  5. ^ Bocklandt, S; Lin, W; Sehl, ME; Sánchez, FJ; Sinsheimer, JS; Horvath, S; Vilain, E (2011). "Epigenetic Predictor of Age". PLOS ONE. 6 (6): e14821. Bibcode:2011PLoSO...614821B. doi:10.1371/journal.pone.0014821. PMC 3120753. PMID 21731603.
  6. ^ a b Horvath, S (2013). "DNA methylation age of human tissues and cell types". Genome Biology. 14 (10): R115. doi:10.1186/gb-2013-14-10-r115. PMC 4015143. PMID 24138928. (Erratum: doi:10.1186/s13059-015-0649-6, PMID 25968125,  Retraction Watch. If the erratum has been checked and does not affect the cited material, please replace {{erratum|...}} with {{erratum|...|checked=yes}}.)
  7. ^ Horvath, S; Mah, V; Lu, AT; Woo, JS; Choi, OW; Jasinska, AJ; Riancho, JA; Tung, S; Coles, NS; Braun, J; Vinters, HV; Coles, LS (2015). "The cerebellum ages slowly according to the epigenetic clock" (PDF). Aging. 7 (5): 294–306. doi:10.18632/aging.100742. PMC 4468311. PMID 26000617. Archived from the original (PDF) on 2015-05-25. Retrieved 2017-06-23.
  8. ^ Marioni, R; Shah, S; McRae, A; Chen, B; Colicino, E; Harris, S; Gibson, J; Henders, A; Redmond, P; Cox, S; Pattie, A; Corley, J; Murphy, L; Martin, N; Montgomery, G; Feinberg, A; Fallin, M; Multhaup, M; Jaffe, A; Joehanes, R; Schwartz, J; Just, A; Lunetta, K; Murabito, JM; Starr, J; Horvath, S; Baccarelli, A; Levy, D; Visscher, P; Wray, N; Deary, I (2015). "DNA methylation age of blood predicts all-cause mortality in later life". Genome Biology. 16 (1): 25. doi:10.1186/s13059-015-0584-6. PMC 4350614. PMID 25633388.
  9. ^ Horvath, S (2015). "Decreased epigenetic age of PBMCs from Italian semi-supercentenarians and their offspring". Aging. 7 (Dec): 1159–70. doi:10.18632/aging.100861. PMC 4712339. PMID 26678252.
  10. ^ Chen, B; Marioni, ME (2016). "DNA methylation-based measures of biological age: meta-analysis predicting time to death". Aging. 8 (9): 1844–1865. doi:10.18632/aging.101020. PMC 5076441. PMID 27690265.
  11. ^ Horvath, S; Erhart, W; Brosch, M; Ammerpohl, O; von Schoenfels, W; Ahrens, M; Heits, N; Bell, JT; Tsai, PC; Spector, TD; Deloukas, P; Siebert, R; Sipos, B; Becker, T; Roecken, C; Schafmayer, C; Hampe, J (2014). "Obesity accelerates epigenetic aging of human liver". Proc Natl Acad Sci U S A. 111 (43): 15538–43. Bibcode:2014PNAS..11115538H. doi:10.1073/pnas.1412759111. PMC 4217403. PMID 25313081.
  12. ^ Horvath, S; Levine, AJ (2015). "HIV-1 infection accelerates age according to the epigenetic clock". J Infect Dis. 212 (10): 1563–73. doi:10.1093/infdis/jiv277. PMC 4621253. PMID 25969563.
  13. ^ Levine, M (2015). "Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer's disease related cognitive functioning". Aging. 7 (Dec): 1198–211. doi:10.18632/aging.100864. PMC 4712342. PMID 26684672.
  14. ^ Marioni, R; Shah, S; McRae, A; Ritchie, S; Muniz-Terrera, GH; SE; Gibson, J; Redmond, P; SR, C; Pattie, A; Corley, J; Taylor, A; Murphy, L; Starr, J; Horvath, S; Visscher, P; Wray, N; Deary, I (2015). "The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936". International Journal of Epidemiology. 44 (4): 1388–1396. doi:10.1093/ije/dyu277. PMC 4588858. PMID 25617346.
  15. ^ Horvath, S (2015). "Increased epigenetic age and granulocyte counts in the blood of Parkinson's disease patients". Aging. 7 (12): 1130–42. doi:10.18632/aging.100859. PMC 4712337. PMID 26655927.
  16. ^ Horvath, S (2016). "Huntington's disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels". Aging. 8 (7): 1485–512. doi:10.18632/aging.101005. PMC 4993344. PMID 27479945.
  17. ^ Levine, M (2016). "Menopause accelerates biological aging". Proc Natl Acad Sci USA. 113 (33): 9327–9332. Bibcode:2016PNAS..113.9327L. doi:10.1073/pnas.1604558113. PMC 4995944. PMID 27457926.
  18. ^ Maierhofer, A (2017). "Accelerated epigenetic aging in Werner syndrome". Aging. 9 (4): 1143–1152. doi:10.18632/aging.101217. PMC 5425119. PMID 28377537.
  19. ^ Horvath, S; Garagnani, P; Bacalini, MG; Pirazzini, C; Salvioli, S; Gentilini, D; Di Blasio, AM; Giuliani, C; Tung, S; Vinters, HV; Franceschi, C (Feb 2015). "Accelerated epigenetic aging in Down syndrome". Aging Cell. 14 (3): 491–5. doi:10.1111/acel.12325. PMC 4406678. PMID 25678027.
  20. ^ Lu, A (2016). "Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum". Nature Communications. 7: 10561. Bibcode:2016NatCo...710561L. doi:10.1038/ncomms10561. PMC 4740877. PMID 26830004.
  21. ^ Lu, A (2017). "Genetic architecture of epigenetic and neuronal ageing rates in human brain regions". Nature Communications. 8 (15353): 15353. Bibcode:2017NatCo...815353L. doi:10.1038/ncomms15353. PMC 5454371. PMID 28516910.
  22. ^ a b Lu, Ake T.; Xue, Luting; Salfati, Elias L.; Chen, Brian H.; Ferrucci, Luigi; Levy, Daniel; Joehanes, Roby; Murabito, Joanne M.; Kiel, Douglas P.; Tsai, Pei-Chien; Yet, Idil; Bell, Jordana T.; Mangino, Massimo; Tanaka, Toshiko; McRae, Allan F.; Marioni, Riccardo E.; Visscher, Peter M.; Wray, Naomi R.; Deary, Ian J.; Levine, Morgan E.; Quach, Austin; Assimes, Themistocles; Tsao, Philip S.; Absher, Devin; Stewart, James D.; Li, Yun; Reiner, Alex P.; Hou, Lifang; Baccarelli, Andrea A.; Whitsel, Eric A.; Aviv, Abraham; Cardona, Alexia; Day, Felix R.; Wareham, Nicholas J.; Perry, John R. B.; Ong, Ken K.; Raj, Kenneth; Lunetta, Kathryn L.; Horvath, Steve (26 January 2018). "GWAS of epigenetic aging rates in blood reveals a critical role for TERT". Nature Communications. 9 (1): 387. Bibcode:2018NatCo...9..387L. doi:10.1038/s41467-017-02697-5. PMC 5786029. PMID 29374233.
  23. ^ Horvath, Steve; Gurven, Michael; Levine, Morgan E.; Trumble, Benjamin C.; Kaplan, Hillard; Allayee, Hooman; Ritz, Beate R.; Chen, Brian; Lu, Ake T.; Rickabaugh, Tammy M.; Jamieson, Beth D.; Sun, Dianjianyi; Li, Shengxu; Chen, Wei; Quintana-Murci, Lluis; Fagny, Maud; Kobor, Michael S.; Tsao, Philip S.; Reiner, Alexander P.; Edlefsen, Kerstin L.; Absher, Devin; Assimes, Themistocles L. (11 August 2016). "An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease". Genome Biology. 17 (1): 171. doi:10.1186/s13059-016-1030-0. PMC 4980791. PMID 27511193.
  24. ^ Quach, Austin; Levine, Morgan E.; Tanaka, Toshiko; Lu, Ake T.; Chen, Brian H.; Ferrucci, Luigi; Ritz, Beate; Bandinelli, Stefania; Neuhouser, Marian L.; Beasley, Jeannette M.; Snetselaar, Linda; Wallace, Robert B.; Tsao, Philip S.; Absher, Devin; Assimes, Themistocles L.; Stewart, James D.; Li, Yun; Hou, Lifang; Baccarelli, Andrea A.; Whitsel, Eric A.; Horvath, Steve (14 February 2017). "Epigenetic clock analysis of diet, exercise, education, and lifestyle factors". Aging. 9 (2): 419–446. doi:10.18632/aging.101168. PMC 5361673. PMID 28198702.
  25. ^ a b Horvath, Steve; Raj, Kenneth (11 April 2018). "DNA methylation-based biomarkers and the epigenetic clock theory of ageing". Nature Reviews Genetics. 19 (6): 371–384. doi:10.1038/s41576-018-0004-3. PMID 29643443. S2CID 4709691.
  26. ^ Zhang, B; Horvath, S (2005). "A general framework for weighted gene co-expression network analysis" (PDF). Stat Appl Genet Mol Biol. 4: Article17. doi:10.2202/1544-6115.1128. PMID 16646834. S2CID 7756201. Archived from the original (PDF) on 2020-09-28. Retrieved 2017-06-23.
  27. ^ Horvath, S; Zhang, B; Carlson, M; Lu, KV; Zhu, S; Felciano, RM; Laurance, MF; Zhao, W; Shu, Q; Lee, Y; Scheck, AC; Liau, LM; Wu, H; Geschwind, DH; Febbo, PG; Kornblum, HI; Cloughesy, TF; Nelson, SF; Mischel, PS (2006). "Analysis of Oncogenic Signaling Networks in Glioblastoma Identifies ASPM as a Novel Molecular Target". PNAS. 103 (46): 17402–17407. Bibcode:2006PNAS..10317402H. doi:10.1073/pnas.0608396103. PMC 1635024. PMID 17090670.
  28. ^ Langfelder, P; Horvath, S (2008). "WGCNA: an R package for weighted correlation network analysis". BMC Bioinformatics. 9: 559. doi:10.1186/1471-2105-9-559. PMC 2631488. PMID 19114008.
  29. ^ Horvath S (2011). Weighted Network Analysis: Applications in Genomics and Systems Biology. Springer Book. 1st Edition., 2011, XXII, 414 p Hardcover ISBN 978-1-4419-8818-8 website
  30. ^ "The Paul G. Allen Frontiers Group Names Five Allen Distinguished Investigators". Cision PR Newswire. June 15, 2017.
  31. ^ "Open Philanthropy award for epigenetic clock research by Steve Horvath". openphilanthropy.org. April 2019.
  32. ^ "2019 Schober award for Steve Horvath from UCLA". University of Halle (Saale) Germany. September 13, 2019.
  33. ^ NIH May 2021 Director Status Report
  34. ^ "ASA 2022 Fellows" (PDF). American Statistical Association. Retrieved 2022-07-20.
  35. ^ "IBS/WNAR Outstanding Impact Award and Lectureship". International Biometric Society.
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