File:Fgene-09-00595-g002.jpg
Size of this preview: 800 × 341 pixels. Other resolutions: 320 × 136 pixels | 1,000 × 426 pixels.
Original file (1,000 × 426 pixels, file size: 98 KB, MIME type: image/jpeg)
 | This is a file from the Wikimedia Commons. Information from its description page there is shown below. Commons is a freely licensed media file repository. You can help. |
Summary
| Description |
English: A model of the different fates of vRNA of flaviviruses. vRNA is replicated by NS5 within the vesicle packets (VP) with the assistance of other nonstructural proteins. Using vRNA, the positive strand (red), as a template, the synthesis of the negative strand (black) by NS5 is depicted. Subsequently, several new copies of vRNA are produced from the dsRNA replication intermediate (not shown). Translation presumably occurs outside of VPs since ribosomes can be visualized adjacent to these structures. vRNA is proposed to exit VPs through a pore to be directly encapsidated and enveloped into juxtaposed ER budding structures. Finally, vRNA is partially degraded by cellular XRN1 which generate sfRNA. sfRNA regulates several host responses including innate immunity at the levels of signal transduction and ISG translation. |
| Date | |
| Source |
Mazeaud C, Freppel W and Chatel-Chaix L (2018) The Multiples Fates of the Flavivirus RNA Genome During Pathogenesis. Front. Genet. 9:595. doi: 10.3389/fgene.2018.00595 https://www.frontiersin.org/articles/10.3389/fgene.2018.00595/full |
| Author | Clément Mazeaud, Wesley Freppel, and Laurent Chatel-Chaix |
Licensing
This file is licensed under the Creative Commons Attribution 4.0 International license.
- You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
- Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
File history
Click on a date/time to view the file as it appeared at that time.
| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 05:14, 17 December 2020 | | 1,000 × 426 (98 KB) | Guest2625 | Uploaded a work by Clément Mazeaud, Wesley Freppel, and Laurent Chatel-Chaix from Mazeaud C, Freppel W and Chatel-Chaix L (2018) The Multiples Fates of the Flavivirus RNA Genome During Pathogenesis. Front. Genet. 9:595. doi: 10.3389/fgene.2018.00595 https://www.frontiersin.org/articles/10.3389/fgene.2018.00595/full with UploadWizard |
File usage
The following page uses this file:
