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Glycolipid 3-alpha-mannosyltransferase

From Wikipedia, the free encyclopedia
glycolipid 3-alpha-mannosyltransferase
Identifiers
EC no.2.4.1.132
CAS no.81181-76-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a glycolipid 3-alpha-mannosyltransferase (EC 2.4.1.132) is an enzyme that catalyzes the chemical reaction in which an alpha-D-mannosyl residue is transferred from GDP-mannose to a lipid-linked oligosaccharide, being attached by an alpha-1,3-D-mannosyl-D-mannose bond.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-mannose:glycolipid 1,3-alpha-D-mannosyltransferase. Other names in common use include mannosyltransferase II, guanosine diphosphomannose-oligosaccharide-lipid II, mannosyltransferase, and GDP-mannose-oligosaccharide-lipid mannosyltransferase II. This enzyme participates in the biosynthesis of n-glycan and glycan structures.

References

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  • Jensen JW, Schutzbach JS (1981). "The biosynthesis of oligosaccharide-lipids. Partial purification and characterization of mannosyltransferase II". J. Biol. Chem. 256 (24): 12899–904. PMID 7309740.