Oxford Nanopore Technologies
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Company type | Public limited company |
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LSE: ONT | |
ISIN | GB00BP6S8Z30 |
Industry | Nanopore sequencing |
Founded | 2005 |
Founders |
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Headquarters | , |
Key people |
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Revenue | ![]() |
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Website | nanoporetech |
Oxford Nanopore Technologies plc is a UK-based company which develops and sells nanopore sequencing products (including the portable DNA sequencer, MinION) for the direct, electronic analysis of single molecules.[2][3][4]
History
[edit]The company was founded in 2005 as a spin-out from the University of Oxford by Hagan Bayley,[5] Gordon Sanghera, and Spike Willcocks, with seed funding from the IP Group.[6] The company made an initial public offering on the London Stock Exchange on 30 September 2021, under the ticker ONT.[7]
In March 2016 the company announced a chemistry upgrade to its nanopore sequencing product 'R9', using a protein nanopore in collaboration with the laboratory of Han Remaut (VIB/Vrije Universiteit Brussel).[8] The company stated in a webcast that R9 is designed to improve error rates and yield.[9]
![](http://upload.wikimedia.org/wikipedia/commons/thumb/6/6f/First-ever_sequencing_of_DNA_in_space%2C_performed_by_Kate_Rubins_on_the_ISS._128f0462_sequencer_1.jpg/220px-First-ever_sequencing_of_DNA_in_space%2C_performed_by_Kate_Rubins_on_the_ISS._128f0462_sequencer_1.jpg)
In July 2016, a MinION nanopore sequencer was included on the ninth NASA/SpaceX commercial cargo resupply services mission to the International Space Station.[10] The aim of the mission was to provide proof of concept for the MinION's functionality in a microgravity environment.[11] During the mission, ISS crew members successfully sequenced DNA from bacteria, bacteriophage and rodents from samples prepared on Earth.[12] Maintaining the MinION device as a research facility on the space station holds the potential to support a number of additional science investigations, any of which could have Earth based applications.[13]
Products
[edit]![](http://upload.wikimedia.org/wikipedia/commons/thumb/5/57/Oxford_Nanopore_MinION_top_cropped.jpg/220px-Oxford_Nanopore_MinION_top_cropped.jpg)
The main products of Oxford Nanopore are:
- MinION:[3][14][15] this harmonica-sized portable protein nanopore sequencing USB device has been commercially available since May 2015[16] after having been launched initially through an early access program, the MinION Access Program (MAP).[17]
- GridION X5: this desktop device has been commercially available since March 2017.[18] The device processes up to five MinION Flow Cells and enables generation of up to 100 Gb of data per run.[19]
- PromethION: this desktop, high throughput device will be available through an access program[20] that opened for registration in July 2015. The device contains channels for 144,000 nanopores (in comparison to MinION’s 512).[21]
- VolTRAX: this device, currently in development, is designed for automated sample preparation so that users do not need a laboratory or lab skills to run the device.[22] Registration for the early access program was opened in October 2016.[23]
- Metrichor: this spinout company from Oxford Nanopore was set up to provide end to end solutions for biological analyses, using nanopore sensing technologies.[24][25]
- SmidgION: a mobile phone sequencer announced in May 2016, currently in development.[26]
These products are intended to be used for the analysis of DNA, RNA, proteins and small molecules with a range of applications in personalized medicine, crop science, and scientific research.[3][27]
References
[edit]- ^ a b c "Annual Results for year ended 31 December 2023" (PDF). Oxford Nanopore Technologies. Retrieved 4 September 2024.
- ^ Eisenstein, M. (2012). "Oxford Nanopore announcement sets sequencing sector abuzz". Nature Biotechnology. 30 (4): 295–6. doi:10.1038/nbt0412-295. PMID 22491260. S2CID 205267199.
- ^ a b c Mikheyev, A. S.; Tin, M. M. Y. (2014). "A first look at the Oxford Nanopore MinION sequencer". Molecular Ecology Resources. 14 (6): 1097–102. doi:10.1111/1755-0998.12324. PMID 25187008. S2CID 3674911.
- ^ Loman, N. J.; Quinlan, A. R. (2014). "Poretools: A toolkit for analyzing nanopore sequence data". Bioinformatics. 30 (23): 3399–401. doi:10.1093/bioinformatics/btu555. PMC 4296151. PMID 25143291.
- ^ "BAYLEY, Prof. (John) Hagan (Pryce)". Who's Who. Vol. 2015 (online edition via Oxford University Press ed.). A & C Black. (Subscription or UK public library membership required.)
- ^ "DNA sequencing: The hole story". The Economist. London. 16 October 2008. Retrieved 19 October 2014.
- ^ "London Stock Exchange welcomes Oxford Nanopore Technologies plc to the Main Market". 11 October 2021.
- ^ "VIB announces collaboration with Oxford Nanopore Technologies on new DNA sequencing nanopore". Retrieved 9 May 2016.
- ^ "No thanks, I've already got one". YouTube. Retrieved 9 May 2016.
- ^ Ramsey, Sarah (21 June 2016). "Next SpaceX Commercial Cargo Launch Now No Earlier Than July 18". Retrieved 25 July 2016.
- ^ "Sequencing DNA in Space - SpaceRef". spaceref.com. Retrieved 25 July 2016.
- ^ Rainey, Kristine (29 August 2016). "First DNA Sequencing in Space a Game Changer". NASA. Retrieved 17 October 2016.
- ^ McIntyre, Alexa B. R.; Rizzardi, Lindsay; Yu, Angela M.; Rosen, Gail L.; Alexander, Noah; Botkin, Douglas J.; John, Kristen K.; Castro-Wallace, Sarah L.; Burton, Aaron S. (10 December 2015). "Nanopore Sequencing in Microgravity". bioRxiv 10.1101/032342.
- ^ Check Hayden, E. (2014). "Data from pocket-sized genome sequencer unveiled". Nature. doi:10.1038/nature.2014.14724.
- ^ Check Hayden, E. (2015). "Pint-sized DNA sequencer impresses first users". Nature. 521 (7550): 15–6. Bibcode:2015Natur.521...15C. doi:10.1038/521015a. PMID 25951262.
- ^ "IP Group PLC – Portfolio company Oxford Nanopore announces £70m fundraising – IP Group PLC". Archived from the original on 21 November 2015. Retrieved 20 November 2015.
- ^ Loman, Nicholas J; Watson, Mick (2015). "Successful test launch for nanopore sequencing". Nature Methods. 12 (4): 303–304. doi:10.1038/nmeth.3327. ISSN 1548-7091. PMID 25825834. S2CID 5604121.
- ^ "Oxford Nanopore Launches GridIon X5 Nanopore Sequencer, Details Product Improvements". GenomeWeb. Retrieved 6 July 2017.
- ^ "GridION X5". nanoporetech.com. Retrieved 6 July 2017.
- ^ "Community - Oxford Nanopore Technologies". Archived from the original on 27 June 2015. Retrieved 17 June 2015.
- ^ "Specifications - Community - Oxford Nanopore Technologies". Archived from the original on 1 June 2016. Retrieved 20 November 2015.
- ^ "Oxford Nanopore CTO Clive Brown's Talk at London Calling: MinION ASIC, volTRAX, promethION". Next Gen Seek. 14 May 2015.
- ^ "VolTRAX". nanoporetech.com. Retrieved 17 October 2016.
- ^ "Oxford Nanopore: we want to create the internet of living things". Wired UK.
- ^ "Metrichor". metrichor.com. Retrieved 17 August 2016.
- ^ "SmidgION - Products & services - Oxford Nanopore Technologies". www2.nanoporetech.com. Archived from the original on 23 August 2016. Retrieved 17 August 2016.
- ^ Check Hayden, Erika (2012). "Nanopore genome sequencer makes its debut". Nature. doi:10.1038/nature.2012.10051. ISSN 1744-7933.