Phillip Thomas Hawkins

Phill Hawkins
Phill Hawkins
Nationality	British
	Scientific career
Fields	immunology, signal transduction
Institutions	Babraham Institute

Phillip (Phill) Thomas Hawkins FRS^[1] (born 5 October 1958) is a molecular biologist, senior group leader at the Babraham Institute.

Phill Hawkins has contributed much to the understanding of inositol lipids functions in eukaryotic cells. Together with his long-time collaborator Leonard R Stephens, he established that PtdIns(4,5)P2 is the main substrate of receptor-controlled Type 1 phosphoinositide 3-kinases (PI3Ks), thus identifying PtdIns(3,4,5)P3 as the key output signal produced by this enzyme.^[2] They identified and isolated the GPCR-activated Type 1B PI3K (PI3KΥ) and, in a sustained body of work, defined its structure, explained its complex pattern of regulation by GβΥ and Ras, and proved its role in inflammatory events in vivo.^[3] They - in parallel with Dario Alessi - identified phosphoinositide-dependent kinase-1 as the PtdIns(3,4,5)P3-activated link between PI3K-1 activation and protein kinase B activation, a key pathway through which PtdIns(3,4,5)P3 formation regulates cell proliferation and survival.^[4]^[5]

Life

Phill Hawkins received a BSc in Biochemistry from the University of Bristol (1980) and a PhD in Biochemistry (1983) from the University of Birmingham. After a post-doctoral training in S.K. & F. Research Ltd, he joined the Molecular Neurobiology unit of the MRC in Cambridge (UK). He joined the AFRC IAPGR (now Babraham Institute) in 1990 and became a group leader in 2003.

Awards and recognition

Phill Hawkins has received several awards, including:

2013, elected Fellow of the Royal Society of London

References

^ "Dr Phillip Hawkins FRS". royalsociety.org. Archived from the original on 13 May 2013. Retrieved 25 February 2014.
^ P.T. Hawkins, T.R. Jackson, L.R. Stephens (1992) Platelet-derived growth factor stimulates synthesis of Ptdlns(3,4,5)P3 by activating a Ptdlns(4,5)P2 3-OH kinase. Nature 358, 157-159
^ L. Stephens, A. Smrcka, F.T. Cooke, T.R. Jackson, P.C. Sternweis, P.T. Hawkins (1994) A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits. Cell 77, 83-93
^ David Stokoe, Leonard R. Stephens, Terry Copeland, Piers R. J. Gaffney, Colin B. Reese, Gavin F. Painter, Andrew B. Holmes, Frank McCormick, Phillip T. Hawkins (1997) Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B. Science 277, 567-570
^ Len Stephens, Karen Anderson, David Stokoe, Hediye Erdjument-Bromage, Gavin F. Painter, Andrew B. Holmes, Piers R.J. Gaffney, Colin B. Reese, Frank McCormick, Paul Tempst, J. Coadwell, Phillip T. Hawkins (1998) Protein Kinase B Kinases That Mediate Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Activation of Protein Kinase B. Science 279, 710-714

External links

Phill Hawkins' group at the Babraham Institute

[1] "Dr Phillip Hawkins FRS". royalsociety.org. Archived from the original on 13 May 2013. Retrieved 25 February 2014.

[2] P.T. Hawkins, T.R. Jackson, L.R. Stephens (1992) Platelet-derived growth factor stimulates synthesis of Ptdlns(3,4,5)P3 by activating a Ptdlns(4,5)P2 3-OH kinase. Nature 358, 157-159

[3] L. Stephens, A. Smrcka, F.T. Cooke, T.R. Jackson, P.C. Sternweis, P.T. Hawkins (1994) A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits. Cell 77, 83-93

[4] David Stokoe, Leonard R. Stephens, Terry Copeland, Piers R. J. Gaffney, Colin B. Reese, Gavin F. Painter, Andrew B. Holmes, Frank McCormick, Phillip T. Hawkins (1997) Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B. Science 277, 567-570

[5] Len Stephens, Karen Anderson, David Stokoe, Hediye Erdjument-Bromage, Gavin F. Painter, Andrew B. Holmes, Piers R.J. Gaffney, Colin B. Reese, Frank McCormick, Paul Tempst, J. Coadwell, Phillip T. Hawkins (1998) Protein Kinase B Kinases That Mediate Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Activation of Protein Kinase B. Science 279, 710-714

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v t e Fellows of the Royal Society elected in 2013
Fellows	Harry Anderson Judy Armitage Keith Ball Mike Bevan Mervyn Bibb Stephen Bloom Gilles Brassard Michael Burrows Jon Crowcroft Ara Darzi Bill Earnshaw Gerry Gilmore Nigel Glover Ray Goldstein Melvyn Goodale Martin Green Gillian Griffiths Joanna Haigh Phil Hawkins Edith Heard Gideon Henderson Guy Lloyd-Jones Stephen P. Long Nicholas Lydon Anne Mills Paul O'Brien William D. Richardson Gareth Roberts Kerry Rowe John Savill Christopher J. Schofield Paul Sharp Stephen Simpson Terry Speed Maria Grazia Spillantini Douglas Stephan Brigitta Stockinger Alan Turnbull Jean-Paul Vincent Andrew Wilkie Terry Wyatt Julia Yeomans Robert Young
Honorary	Bill Bryson
Foreign	Margaret Buckingham Chen Zhu John Hutchinson Eric Kandel Elliott Lieb K. C. Nicolaou Randy Schekman Eli Yablonovitch
Royal	Prince Andrew, Duke of York