This page exists specifically to discuss and present/edit proposals for the addition of a new section on the main CFS article page:

Proposed structure and content 1

Nosological Developments

The medical classification (nosology) of CFS is subject to ongoing research which is variously focussed upon epidemiology, upon [clinical description]] and upon the establishment of biomarkers.

Epidemiology

Recent work o the epidemiology of CFS is limited to a single study on prevalence in a developing society.

Study	Reference	Authors	URL
Comparative epidemiology of chronic fatigue syndrome in Brazilian and British primary care: prevalence and recognition	The British Journal of Psychiatry (2009) 194: 117-122 doi: 10.1192/bjp.bp.108.051813	Hyong Jin Cho et al	[1]

Clinical Descriptions

In addition to the operative descriptions employed by national health organisations such as the CDC and NICE, research has produced other clinical descriptions which as yet have not met with general medical consensus:

Study	Reference	Authors	URL
Immunological aspects of chronic fatigue syndrome	doi:10.1016/j.autrev.2008.08.003	Lorussoa et al	[2]
Conceptual Model for Physical Therapist Management of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis	doi: 10.2522/?ptj.20090047 Physical Therapy April 2010 vol. 90 no. 4 602-614	Davenport et al	[3]
Neuropsychological functioning, illness perception, mood and quality of life in chronic fatigue syndrome, autoimmune thyroid disease and healthy participants	Psychological Medicine (2009), 39, 1567–1576. doi:10.1017/S0033291708004960	Dickson et al	[4]
Seven genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis: a detailed analysis of gene networks and clinical phenotypes	J Clin Pathol2008;61:730-739 doi:10.1136/jcp.2007.053553	Kerr et al	[5]
Can sustained arousal explain the Chronic Fatigue Syndrome?	Behavioral and Brain Functions 2009, 5:10 doi:10.1186/1744-9081-5-10	Wyller et al	[6]
Chronic fatigue syndrome: illness severity, sedentary lifestyle, blood volume and evidence of diminished cardiac function	Clinical Science (2010) 118, (125–135)	Hurwitz et al	[7]
Chronic fatigue syndrome: aetiology, diagnosis and treatment	BMC Psychiatry 2009, 9(Suppl 1):S1 doi:10.1186/1471-244X-9-S1-S1	Fernández et al	[8]
Prefrontal cortex oxygenation during incremental exercise in chronic fatigue syndrome	DOI: 10.1111/j.1475-097X.2008.00822.x Clinical Physiology and Functional Imaging	Neary et al	[9]
Myalgic encephalomyelitis: International Consensus Criteria.	J Intern Med. 2011 Oct;270(4):327-38. doi: 10.1111/j.1365-2796.2011.02428.x	Carruthers BM et al	[10]

Biomarkers

Successful identification of biomarkers would impact upon future directions in both the epidemiology and in the clinical description of CFS. There is no current general medical consensus on CFS biomarkers however the following have been proposed:

Biomarker	Study	Reference	Author	URL
ACCN3 (ASIC3	Moderate Exercise Increases Expression for Sensory, Adrenergic, and Immune Genes in Chronic Fatigue Syndrome Patients But Not in Normal Subjects	doi:10.1016/j.jpain.2009.06.003	Light et al	[11]
CD8	Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis	Journal of Translational Medicine 2011, 9:81	Brenu et al	[12]
CD26	Biomarkers in Chronic Fatigue Syndrome: Evaluation of Natural Killer Cell Function and Dipeptidyl Peptidase IV/CD26	PLoS ONE 5(5): e10817. doi:10.1371/journal.pone.0010817	Fletcher et al	[13]
Cortisol	Alterations in Diurnal Salivary Cortisol Rhythm in a Population-Based Sample of Cases With Chronic Fatigue Syndrome	Psychosomatic Medicine April 1, 2008 vol. 70 no. 3 298-305 doi: 10.1097/?PSY.0b013e3181651025	James et al	[14]
FoxP3	Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis	Journal of Translational Medicine 2011, 9:81	Brenu et al	[15]
IFN-g	Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis	Journal of Translational Medicine 2011, 9:81	Brenu et al	[16]
IL1	Plasma cytokines in women with chronic fatigue syndrome	Journal of Translational Medicine 2009, 7:96 doi:10.1186/1479-5876-7-96,	Fletcher et al,	[17]
IL1	Evidence for inflammation and activation of cell-mediated immunity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Increased interleukin-1, tumor necrosis factor-a, PMN-elastase, lysozyme and neopterin	doi:10.1016/j.jad.2011.09.004 \|	Maesa et al	[18]
IL4	Plasma cytokines in women with chronic fatigue syndrome	Journal of Translational Medicine 2009, 7:96 doi:10.1186/1479-5876-7-96	Fletcher et al	[19]
IL5	Plasma cytokines in women with chronic fatigue syndrome	Journal of Translational Medicine 2009, 7:96 doi:10.1186/1479-5876-7-96,	Fletcher et al,	[20]
IL6	Gene Expression Subtypes in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis	The Journal of Infectious Diseases 2008; 197:1171– 84 DOI: 10.1086/533453	Beverly et al	[[21]]
IL10	Moderate Exercise Increases Expression for Sensory, Adrenergic, and Immune Genes in Chronic Fatigue Syndrome Patients But Not in Normal Subjects	doi:10.1016/j.jpain.2009.06.003	Light et al	[22]
IL10	Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis	Journal of Translational Medicine 2011, 9:81	Brenu et al	[23]
Lipoteichoic acid	Plasma cytokines in women with chronic fatigue syndrome	Journal of Translational Medicine 2009, 7:96 doi:10.1186/1479-5876-7-96,	Fletcher et al,	[24]
Lysozyme	Evidence for inflammation and activation of cell-mediated immunity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Increased interleukin-1, tumor necrosis factor-a, PMN-elastase, lysozyme and neopterin	doi:10.1016/j.jad.2011.09.004 \|	Maesa et al	[25]
Na-K-Cl cotransporter(NKCC)	Biomarkers in Chronic Fatigue Syndrome: Evaluation of Natural Killer Cell Function and Dipeptidyl Peptidase IV/CD26	PLoS ONE 5(5): e10817. doi:10.1371/journal.pone.0010817	Fletcher et al	[26]
Na-K-Cl cotransporter(NKCC)	Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis	Journal of Translational Medicine 2011, 9:81	Brenu et al	[27]
Neopterin	Evidence for inflammation and activation of cell-mediated immunity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Increased interleukin-1, tumor necrosis factor-a, PMN-elastase, lysozyme and neopterin	doi:10.1016/j.jad.2011.09.004 \|	Maesa et al	[28]
P2RX4	Moderate Exercise Increases Expression for Sensory, Adrenergic, and Immune Genes in Chronic Fatigue Syndrome Patients But Not in Normal Subjects	doi:10.1016/j.jpain.2009.06.003	Light et al	[29]
P2RX5	Moderate Exercise Increases Expression for Sensory, Adrenergic, and Immune Genes in Chronic Fatigue Syndrome Patients But Not in Normal Subjects	doi:10.1016/j.jpain.2009.06.003	Light et al	[30]
Neuropeptide Y	Plasma neuropeptide Y: a biomarker for symptom severity in chronic fatigue syndrome	Behavioral and Brain Functions 2010, 6:76	Fletcher et al	[31]
Plasma peroxides	Increased plasma peroxides as a marker of oxidative stress in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).	Med Sci Monit. 2011 Apr;17(4):SC11-5.	Maes et al	[32]
Neutrophil elastase	Evidence for inflammation and activation of cell-mediated immunity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Increased interleukin-1, tumor necrosis factor-a, PMN-elastase, lysozyme and neopterin	doi:10.1016/j.jad.2011.09.004 \|	Maesa et al	[33]
LDL	Increased plasma peroxides as a marker of oxidative stress in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).	Med Sci Monit. 2011 Apr;17(4):SC11-5.	Maes et al	[34]
TNFa	Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis	Journal of Translational Medicine 2011, 9:81	Brenu et al	[[35]]
Toll-like receptor	Moderate Exercise Increases Expression for Sensory, Adrenergic, and Immune Genes in Chronic Fatigue Syndrome Patients But Not in Normal Subjects	doi:10.1016/j.jpain.2009.06.003	Light et al	[36]

--In Vitro Infidelium (talk) 15:58, 15 December 2011 (UTC)[reply]