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16S rRNA (guanine527-N7)-methyltransferase

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16S rRNA (guanine527-N7)-methyltransferase
Identifiers
EC no.2.1.1.170
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
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NCBIproteins

16S rRNA (guanine527-N7)-methyltransferase (EC 2.1.1.170, ribosomal RNA small subunit methyltransferase G, 16S rRNA methyltransferase RsmG, GidB, rsmG (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (guanine527-N7)-methyltransferase.[1][2] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + guanine527 in 16S rRNA S-adenosyl-L-homocysteine + N7-methylguanine527 in 16S rRNA

The enzyme specifically methylates guanine527 at N7 in 16S rRNA.

References

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  1. ^ Okamoto S, Tamaru A, Nakajima C, Nishimura K, Tanaka Y, Tokuyama S, Suzuki Y, Ochi K (February 2007). "Loss of a conserved 7-methylguanosine modification in 16S rRNA confers low-level streptomycin resistance in bacteria". Molecular Microbiology. 63 (4): 1096–106. doi:10.1111/j.1365-2958.2006.05585.x. PMID 17238915.
  2. ^ Romanowski MJ, Bonanno JB, Burley SK (June 2002). "Crystal structure of the Escherichia coli glucose-inhibited division protein B (GidB) reveals a methyltransferase fold". Proteins. 47 (4): 563–7. doi:10.1002/prot.10121. PMID 12001236.
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