The Lions debuted updated uniforms with a classic font including a new alternate consisting of blue lettering on black jerseys and matching black pants and black socks and a blue helmet with a black lion graphic.[1]
The Lions opened the regular season at home against the Los Angeles Rams. The Rams opened the scoring in the first quarter via a 41-yard field goal by Joshua Karty. The Lions scored ten points in the second quarter via a 25-yard field goal by Jake Bates and a one-yard touchdown run from Jahmyr Gibbs, which made the score 10–3 in favor of Detroit at half-time. The Lions extended their lead in the third quarter via a 52-yard touchdown pass from Jared Goff to Jameson Williams. The Rams responded with a two-yard touchdown run from Kyren Williams. The Rams scored ten points in the fourth quarter via a 26-yard field goal by Karty and a nine-yard touchdown pass from Matthew Stafford to Cooper Kupp, to regain the lead. The Lions responded with a 32-yard field goal by Bates with 17 seconds remaining in the game to force overtime. On the first possession of overtime, the Lions scored via a one-yard touchdown run from David Montgomery, making the final score 26–20 in favor of Detroit.
In week 2, the Lions hosted the Tampa Bay Buccaneers. Tampa Bay scored six points in the first quarter via two field goals by Chase McLaughlin from 30-yards, and 55-yards, respectively. The Lions responded with a 22-yard field goal by Jake Bates. The Lions scored in the second quarter via a 35-yard field goal by Bates to tie the game. The Buccaneers regained the lead via a 41-yard touchdown pass from Baker Mayfield to Chris Godwin, which made the score 13–6 in favor of Tampa Bay at half-time. The Lions scored ten points in the third quarter via a 32-yard field goal by Bates and a one-yard touchdown run from David Montgomery to take their first lead of the game. The Buccaneers responded with an 11-yard touchdown run from Mayfield to regain the lead. After a scoreless fourth quarter, the Lions' attempted comeback failed after turning the ball over on downs after three consecutive incomplete passes by Jared Goff, making the final score 20–16 in favor of Tampa Bay. Aidan Hutchinson recorded 4.5 sacks, the third player in NFL history to record four or more sacks in a game after Willie Gay and Keith Ferguson.[65]
In week 3, the Lions visited the Arizona Cardinals. The Lions opened the scoring in the first quarter via a one-yard touchdown run form David Montgomery. The Cardinals responded with a ten-yard touchdown pass from Kyler Murray to Marvin Harrison Jr. to tie the game. The Lions scored 13 points in the second quarter via a five-yard touchdown pass from Jared Goff to Amon-Ra St. Brown and a 20-yard touchdown pass from Goff to Jahmyr Gibbs. The Cardinals scored the final points of the quarter via a 42-yard field goal by Matt Prater as time expired in the first half, which made the score 20–10 in favor of Detroit at half-time. After a scoreless third quarter, the Cardinals scored the only points of the fourth quarter via a 45-yard field goal by Prater, making the final score 20–13 in favor of Detroit.
In week 4, the Lions hosted the Seattle Seahawks. The Lions opened the scoring in the first quarter via a one-yard touchdown run from David Montgomery. The Lions scored 14 points in the second quarter via two rushing touchdowns by Jahmyr Gibbs from three-yards, and one-yard, respectively. The Seahawks responded with a one-yard touchdown run from Kenneth Walker III, which made the score 21–7 in favor of Detroit at half-time. The Seahawks scored 13 points in the third quarter via a nine-yard touchdown pass from Geno Smith to AJ Barner and a one-yard touchdown run from Walker III. The Lions scored 14 points in the quarter via a seven-yard touchdown pass from Amon-Ra St. Brown to Jared Goff, and a 70-yard touchdown pass from Goff to Jameson Williams. The teams exchanged touchdowns in the fourth quarter, first a 21-yard touchdown run from Walker III for the Seahawks, then an eight-yard touchdown pass from Goff to St. Brown for the Lions. The Seahawks scored the final points of the game after Goff was sacked in the endzone by Dre'Mont Jones for a safety, making the final score 42–29 in favor of Detroit. The win marked Lions' first victory against the Seahawks since 2012, snapping a six-game losing streak.[66] Goff finished the game a perfect 18-for-18 for 292 yards and two touchdowns, becoming the first player in NFL history with a perfect completion percentage in a game with a minimum of 15 passes.[67][68]
^When breaking ties for three or more teams under the NFL's rules, they are first broken within divisions, then comparing only the highest-ranked remaining team from each division.