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4-Cyano-3-(trifluoromethyl)aniline

From Wikipedia, the free encyclopedia
4-Cyano-3-(trifluoromethyl)aniline
Names
Preferred IUPAC name
4-Amino-2-(trifluoromethyl)benzonitrile
Other names
4-Cyano-3-(trifluoromethyl)aniline
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.109.189 Edit this at Wikidata
UNII
  • C1=CC(=C(C=C1N)C(F)(F)F)C#N
Properties
C8H5F3N2
Molar mass 186.137 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

4-Cyano-3-(trifluoromethyl)aniline, also known as 4-amino-2-(trifluoromethyl)benzonitrile, is a cyanated and trifluoromethylated derivative of aniline. It is the starting material in one of the chemical syntheses of the nonsteroidal antiandrogen bicalutamide.[1]

References

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  1. ^ Tucker H, Crook JW, Chesterson GJ (1988). "Nonsteroidal antiandrogens. Synthesis and structure-activity relationships of 3-substituted derivatives of 2-hydroxypropionanilides". Journal of Medicinal Chemistry. 31 (5): 954–9. doi:10.1021/jm00400a011. PMID 3361581.