ATPase Domain 3B
 | This article may be too technical for most readers to understand. (May 2020) |
 | |
| ATAD3B | |
|---|---|
| Alliases | TOB3, AAA-TOB3, KIAA 1273 |
| External IDs | NCBI: AAH02542.1 |
| Gene Location (Human) | |
| Testing | dkjfdkj |
ATPase Domain 3B (ATAD3B) is a protein that in humans is encoded by the ATAD3B gene. [citation needed] ATAD3 is part of the AAA protein family. The function of ATAD3B is not yet well understood by the scientific community. In humans the gene is located at 1p36.33.
Function
[edit]
ATAD3B is associated with the mitochondria. The C terminus is anchored in the mitochondrial inter membrane space.[1]
The protein is linked with the pluripotency of stem cells. The ATAD3A gene is targeted by c-Myc[1] which is one of four factors needed to create induced pluripotent stem (i-PS) cells from mouse embryonic fibroblasts(MEFs).[2]
Its expression is linked to cell cycle function and tumor growth.[3] When ATAD3B was overexpressed, cell duplication took an extra three hours by spending a longer time in G1 phase.[3] Abnormal expression levels of ATAD3B has been linked to chemoresistance. Overexpression of ATAD3B was the found to be the strongest factor in breast cancer survival rates.[4]
Characteristics
[edit]A mutation in the stop codon means that ATAD3B has a 62 amino acid longer UTR.[5]
References
[edit]- ^ a b Merle, Nicolas; Féraud, Olivier; Gilquin, Benoit; Hubstenberger, Arnaud; Kieffer-Jacquinot, Sylvie; Assard, Nicole; Bennaceur-Griscelli, Annelise; Honnorat, Jérôme; Baudier, Jacques (2012-07-01). "ATAD3B is a human embryonic stem cell specific mitochondrial protein, re-expressed in cancer cells, that functions as dominant negative for the ubiquitous ATAD3A". Mitochondrion. 12 (4): 441–448. doi:10.1016/j.mito.2012.05.005. ISSN 1567-7249. PMID 22664726.
- ^ Takahashi, Kazutoshi; Yamanaka, Shinya (2006-08-25). "Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors". Cell. 126 (4): 663–676. doi:10.1016/j.cell.2006.07.024. hdl:2433/159777. ISSN 0092-8674. PMID 16904174. S2CID 1565219.
- ^ a b Hubstenberger, Arnaud; Labourdette, Gérard; Baudier, Jacques; Rousseau, Denis (2008-09-10). "ATAD 3A and ATAD 3B are distal 1p-located genes differentially expressed in human glioma cell lines and present in vitro anti-oncogenic and chemoresistant properties". Experimental Cell Research. 314 (15): 2870–2883. doi:10.1016/j.yexcr.2008.06.017. ISSN 0014-4827. PMID 18639545.
- ^ Ovaska, Kristian; Matarese, Filomena; Grote, Korbinian; Charapitsa, Iryna; Cervera, Alejandra; Liu, Chengyu; Reid, George; Seifert, Martin; Stunnenberg, Hendrik G.; Hautaniemi, Sampsa (2013-06-20). Tucker-Kellogg, Greg (ed.). "Integrative Analysis of Deep Sequencing Data Identifies Estrogen Receptor Early Response Genes and Links ATAD3B to Poor Survival in Breast Cancer". PLOS Computational Biology. 9 (6): e1003100. Bibcode:2013PLSCB...9E3100O. doi:10.1371/journal.pcbi.1003100. ISSN 1553-7358. PMC 3688481. PMID 23818839.
- ^ Li, Shuijie; Rousseau, Denis (2012). "ATAD3, a vital membrane bound mitochondrial ATPase involved in tumor progression". Journal of Bioenergetics and Biomembranes. 44 (1): 189–197. doi:10.1007/s10863-012-9424-5. ISSN 0145-479X. PMID 22318359. S2CID 11106754.