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Asialoglycoprotein receptor 1

From Wikipedia, the free encyclopedia
ASGR1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesASGR1, ASGPR, ASGPR1, CLEC4H1, HL-1, asialoglycoprotein receptor 1
External IDsOMIM: 108360; MGI: 88081; HomoloGene: 1263; GeneCards: ASGR1; OMA:ASGR1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001197216
NM_001671

NM_001291131
NM_001291132
NM_009714

RefSeq (protein)

NP_001184145
NP_001662

NP_001278060
NP_001278061
NP_033844

Location (UCSC)Chr 17: 7.17 – 7.18 MbChr 11: 69.94 – 69.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Asialoglycoprotein receptor 1 is a protein that in humans is encoded by the ASGR1 gene.[5]

Function

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This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000141505Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020884Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Asialoglycoprotein receptor 1". Retrieved 2018-10-02.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.