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BTAF1

From Wikipedia, the free encyclopedia
BTAF1
Identifiers
AliasesBTAF1, MOT1, TAF(II)170, TAF172, TAFII170, B-TFIID TATA-box binding protein associated factor 1
External IDsOMIM: 605191; MGI: 2147538; HomoloGene: 31978; GeneCards: BTAF1; OMA:BTAF1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003972

NM_001080706

RefSeq (protein)

NP_003963
NP_003963.1

NP_001074175

Location (UCSC)Chr 10: 91.92 – 92.03 MbChr 19: 36.9 – 36.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

TATA-binding protein-associated factor 172 is a protein that in humans is encoded by the BTAF1 gene.[5][6][7]

Function

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Initiation of transcription by RNA polymerase II requires the assistance of TATA box-binding protein (TBP; MIM 600075) and TBP-associated factors, or TAFs (e.g., TAF2B; MIM 604912), in 2 distinct complexes, TFIID and B-TFIID. The TFIID complex is composed of TBP and more than 8 TAFs. However, the majority of TBP is present in the B-TFIID complex, which is composed of TBP and TAFII170, also called TAF172, and has DNA-dependent ATPase activity.[supplied by OMIM][7]

Interactions

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BTAF1 has been shown to interact with TATA binding protein.[6][8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000095564Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040565Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ van der Knaap JA, Borst JW, van der Vliet PC, Gentz R, Timmers HT (Dec 1997). "Cloning of the cDNA for the TATA-binding protein-associated factorII170 subunit of transcription factor B-TFIID reveals homology to global transcription regulators in yeast and Drosophila". Proc Natl Acad Sci U S A. 94 (22): 11827–32. Bibcode:1997PNAS...9411827V. doi:10.1073/pnas.94.22.11827. PMC 23617. PMID 9342322.
  6. ^ a b Chicca JJ, Auble DT, Pugh BF (Mar 1998). "Cloning and Biochemical Characterization of TAF-172, a Human Homolog of Yeast Mot1". Mol Cell Biol. 18 (3): 1701–10. doi:10.1128/MCB.18.3.1701. PMC 108885. PMID 9488487.
  7. ^ a b "Entrez Gene: BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae)".
  8. ^ Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (May 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5605–10. Bibcode:1997PNAS...94.5605S. doi:10.1073/pnas.94.11.5605. PMC 20825. PMID 9159119.
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Further reading

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