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Bombinin

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Bombinin
Identifiers
SymbolBombinin
PfamPF05298
InterProIPR007962
OPM superfamily211
OPM protein2ap8
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

The bombinin family of antimicrobial peptides includes the bombinin and maximin proteins from Bombina maxima (Giant fire-bellied toad). Two groups of antimicrobial peptides have been isolated from skin secretions of B. maxima. Peptides in the first group, named maximins 1, 2, 3, 4 and 5, are structurally related to bombinin-like peptides (BLPs). Unlike BLPs, sequence variations in maximins occurred all through the molecules. In addition to the potent antimicrobial activity, cytotoxicity against tumour cells and spermicidal action of maximins, maximin 3 possessed a significant anti-Simian-Human immunodeficiency virus (HIV) activity. Maximins 1 and 3 have been found to be toxic to mice. Peptides in the second group, termed maximins H1, H2, H3 and H4, are homologous with bombinin H peptides.[1]

References

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  1. ^ Lai R, Zheng YT, Shen JH, Liu GJ, Liu H, Lee WH, Tang SZ, Zhang Y (March 2002). "Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima". Peptides. 23 (3): 427–435. doi:10.1016/S0196-9781(01)00641-6. PMID 11835991. S2CID 1421665.
This article incorporates text from the public domain Pfam and InterPro: IPR007962