CEP250

CEP250
Identifiers
Aliases	CEP250, C-NAP1, CEP2, CNAP1, centrosomal protein 250, CRDHL2
External IDs	OMIM: 609689; MGI: 108084; HomoloGene: 38286; GeneCards: CEP250; OMA:CEP250 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) Band 20q11.22 Start 35,455,164 bp End 35,519,280 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 H1 Start 155,798,378 bp End 155,840,820 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve ventricular zone granulocyte ganglionic eminence stromal cell of endometrium cerebellar hemisphere right hemisphere of cerebellum Achilles tendon lymph node epithelium of colon Top expressed in neural layer of retina granulocyte tail of embryo ventricular zone genital tubercle yolk sac thymus Jacobson's organ zygote secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein domain specific binding protein C-terminus binding protein binding protein kinase binding Cellular component cytoplasm cytosol centrosome cell projection cilium microtubule organizing center perinuclear region of cytoplasm centriole extracellular exosome cytoskeleton protein-containing complex Biological process protein localization to organelle protein localization regulation of centriole-centriole cohesion centriole-centriole cohesion G2/M transition of mitotic cell cycle cell cycle mitotic cell cycle ciliary basal body-plasma membrane docking positive regulation of protein localization to centrosome non-motile cilium assembly regulation of G2/M transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11190 16328 Ensembl ENSG00000126001 ENSMUSG00000038241 UniProt Q9BV73 Q60952 RefSeq (mRNA) NM_001035518 NM_007186 NM_001318219 NM_001129999 NM_001130000 NM_008383 NM_177217 RefSeq (protein) NP_001305148 NP_009117 NP_001123471 NP_001123472 NP_032409 NP_796191 Location (UCSC) Chr 20: 35.46 – 35.52 Mb Chr 2: 155.8 – 155.84 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Centrosome-associated protein CEP250 is a protein that in humans is encoded by the CEP250 gene. This gene encodes a core centrosomal protein required for centriole-centriole cohesion during interphase of the cell cycle. The encoded protein dissociates from the centrosomes when parental centrioles separate at the beginning of mitosis. The protein associates with and is phosphorylated by NIMA-related kinase 2, which is also associated with the centrosome. Furthermore, CEP135 is also required for the centriolar localization of CEP250.

External links

• Human CEP250 genome location and CEP250 gene details page in the UCSC Genome Browser.

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Faragher AJ, Fry AM (2004). "Nek2A kinase stimulates centrosome disjunction and is required for formation of bipolar mitotic spindles". Mol. Biol. Cell. 14 (7): 2876–89. doi:10.1091/mbc.E03-02-0108. PMC 165683. PMID 12857871.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mayor T, Hacker U, Stierhof YD, Nigg EA (2003). "The mechanism regulating the dissociation of the centrosomal protein C-Nap1 from mitotic spindle poles". J. Cell Sci. 115 (Pt 16): 3275–84. doi:10.1242/jcs.115.16.3275. PMID 12140259.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
• Mayor T, Stierhof YD, Tanaka K, et al. (2000). "The Centrosomal Protein C-Nap1 Is Required for Cell Cycle–Regulated Centrosome Cohesion". J. Cell Biol. 151 (4): 837–46. doi:10.1083/jcb.151.4.837. PMC 2169446. PMID 11076968.
• Hirsch DS, Pirone DM, Burbelo PD (2001). "A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes". J. Biol. Chem. 276 (2): 875–83. doi:10.1074/jbc.M007039200. PMID 11035016.
• Helps NR, Luo X, Barker HM, Cohen PT (2001). "NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1". Biochem. J. 349 (Pt 2): 509–18. doi:10.1042/0264-6021:3490509. PMC 1221174. PMID 10880350.