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CPM (gene)

From Wikipedia, the free encyclopedia
CPM
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCPM, carboxypeptidase M
External IDsOMIM: 114860; MGI: 1917824; HomoloGene: 35367; GeneCards: CPM; OMA:CPM - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001005502
NM_001874
NM_198320

NM_027468

RefSeq (protein)

NP_001005502
NP_001865
NP_938079

NP_081744

Location (UCSC)Chr 12: 68.84 – 68.97 MbChr 10: 117.47 – 117.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Carboxypeptidase M is an enzyme that in humans is encoded by the CPM gene.[5][6]

Function

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The protein encoded by this gene is a membrane-bound arginine/lysine carboxypeptidase. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the amino and carboxy termini and has 6 potential asparagine-linked glycosylation sites. The active site residues of carboxypeptidases A and B are conserved in this protein. Three alternatively spliced transcript variants encoding the same protein have been described for this gene.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135678Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020183Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kas K, Schoenmakers EF, Van de Ven WJ (November 1995). "Physical map location of the human carboxypeptidase M gene (CPM) distal to D12S375 and proximal to D12S8 at chromosome 12q15". Genomics. 30 (2): 403–5. PMID 8586455.
  6. ^ a b "Entrez Gene: CPM carboxypeptidase M".
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Further reading

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