Corticotropin-releasing hormone binding protein family
| Corticotropin-releasing hormone binding protein (CRH-BP) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | CRH-BP | ||||||||
| Pfam | PF05428 | ||||||||
| InterPro | IPR008435 | ||||||||
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Corticotropin-releasing hormone binding protein (CRH-BP) binds corticotropin-releasing hormone (CRH) and several related peptide hormones (urocortin 1, urotensin 1, and sauvagine).[1] It is an ancient, highly conserved protein whose origin predates the divergence of protostomes and deuterostomes.[2]
Corticotropin-releasing hormone (CRH) plays multiple roles in vertebrate species. It is the major hypothalamic releasing factor for pituitary adrenocorticotropin secretion,[2] and is a neurotransmitter or neuromodulator at other sites in the central nervous system. In non-mammalian vertebrates, CRH not only acts as a neurotransmitter and hypophysiotropin, it also acts as a potent thyrotropin-releasing factor,[3] allowing CRH to regulate both the adrenal and thyroid axes, especially in development.
Corticotropin-releasing factor binding protein (CRH-BP) is thought to play an inhibitory role in which it binds CRH and other CRH-like ligands and prevents the activation of CRH receptors 1 and 2. There is however evidence that CRH-BP may also exhibit diverse extra and intracellular roles in a cell specific fashion and at specific times in development.[4]
Human proteins
[edit]References
[edit]- ^ Ketchesin, Kyle D.; Stinnett, Gwen S.; Seasholtz, Audrey F. (2017-09-03). "Corticotropin-releasing hormone-binding protein and stress: from invertebrates to humans". Stress. 20 (5): 449–464. doi:10.1080/10253890.2017.1322575. ISSN 1025-3890. PMC 7885796. PMID 28436309. S2CID 41347737.
- ^ a b Huising, Mark O.; Flik, Gert (May 2005). "The Remarkable Conservation of Corticotropin-Releasing Hormone (CRH)-Binding Protein in the Honeybee ( Apis mellifera ) Dates the CRH System to a Common Ancestor of Insects and Vertebrates". Endocrinology. 146 (5): 2165–2170. doi:10.1210/en.2004-1514. hdl:2066/33202. ISSN 0013-7227. PMID 15718273.
- ^ De Groef, Bert; Van der Geyten, Serge; Darras, Veerle M.; Kühn, Eduard R. (March 2006). "Role of corticotropin-releasing hormone as a thyrotropin-releasing factor in non-mammalian vertebrates". General and Comparative Endocrinology. 146 (1): 62–68. doi:10.1016/j.ygcen.2005.10.014. PMID 16337947.
- ^ Seasholtz AF, Valverde RA, Denver RJ (2002). "Corticotropin-releasing hormone-binding protein: biochemistry and function from fishes to mammals". J. Endocrinol. 175 (1): 89–97. doi:10.1677/joe.0.1750089. PMID 12379493.