Draft:Meluadrine
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Clinical data | |
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Other names | HSR-81; (R)-4-Hydroxytulobuterol |
Drug class | Sympathomimetic; Tocolytic; β2-Adrenergic receptor agonist |
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Chemical and physical data | |
Formula | C12H18ClNO2 |
Molar mass | 243.73 g·mol−1 |
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Meluadrine (INN ), also known as meluadrine tartrate (JAN ; developmental code name HSR-81) in the case of the tartrate salt, is a sympathomimetic and β2-adrenergic receptor agonist which was studied as a tocolytic drug but was never marketed.[1][2][3][4][5] It was first described in the literature by 1994.[6] The drug is also known as (R)-4-hydroxytulobuterol and is an active metabolite of tulobuterol.[7]
References
[edit]- ^ Ballard A, Narduolo S, Ahmad HO, Cosgrove DA, Leach AG, Buurma NJ (June 2019). "The problem of racemization in drug discovery and tools to predict it". Expert Opin Drug Discov. 14 (6): 527–539. doi:10.1080/17460441.2019.1588881. PMID 30882254.
- ^ https://cdn.who.int/media/docs/default-source/international-nonproprietary-names-(inn)/stembook-2018.pdf#page=95
- ^ Matsuda Y, Kouno S, Sakamoto H, Ikenoue T (October 2002). "Effects of meluadrine tartrate and ritodrine hydrochloride on oxytocin-induced uterine contraction, uterine arterial blood flow and maternal cardiovascular function in pregnant goats". Jpn J Pharmacol. 90 (2): 107–13. doi:10.1254/jjp.90.107. PMID 12419879.
- ^ Matsuda Y, Kouno S, Sakamoto H, Ikenoue T (October 2002). "Effects of meluadrine tartrate on maternal metabolic responses and fetal hemodynamics in pregnant goats". Jpn J Pharmacol. 90 (2): 114–120. doi:10.1254/jjp.90.114. PMID 12419880.
- ^ Ohashi T, Hashimoto S, Morikawa K, Kato H, Ito Y, Asano M, Azuma H (July 1996). "Potent inhibition of spontaneous rhythmic contraction by a novel beta 2-adrenoceptor agonist, HSR-81, in pregnant rat uterus". Eur J Pharmacol. 307 (3): 315–322. doi:10.1016/0014-2999(96)00277-4. PMID 8836620.
- ^ Hashimoto, S. (1994). Inhibitory effect of HSR-81, a novel β2-adrenoceptor agonist, on uterine contraction in late pregnancy. Jpn J Pharmacol, 64, 211. https://scholar.google.com/scholar?cluster=13515647726305291847
- ^ Glushkova, M. A.; Popkov, S. V.; Burdeinyi, M. L. (2020). "Synthesis of the β2-Agonist Tulobuterol and Its Metabolite 4-Hydroxytulobuterol". Russian Journal of Organic Chemistry. 56 (3). Pleiades Publishing Ltd: 390–394. doi:10.1134/s1070428020030045. ISSN 1070-4280.