Draft:Oligonucleotide insecticides
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![](http://upload.wikimedia.org/wikipedia/commons/thumb/1/19/Antisense_DNA_oligonucleotide.png/220px-Antisense_DNA_oligonucleotide.png)
The equal sign between short (11-18 nt long) unmodified DNA oligonucleotides and contact insecticides was first established on the sponge moth Lymantria dispar by Crimean molecular geneticist Oberemok V.V. in 2008 [1][2][3]. By the beginning of 2008, there was no data in the world literature on the possibility of using RNase H-dependent antisense DNA oligonucleotides as contact DNA insecticides for insect pest control. Generally, insect pest rRNAs serve as targets for them [4].
Oligonucleotide insecticides represent antisense DNA technology and act through DNA containment mechanism that consists of 2 steps: at first step, antisense DNA oligonucleotide complementarily interacts with target rRNA (in other words, ‘arrests’ target rRNA) and blocks normal functioning of ribosomes; at second step, RNase H cleaves target rRNA and substantial decrease in its concentration occurs [5].
Today, oligonucleotide insecticides (DNA insecticides) is the only biotechnology that uses short unmodified antisense DNA oligonucleotides in plant protection [6][7]. According to the authors, the use of DNA insecticides, as next-generation class of insecticides, can reduce the concentration of modern chemical insecticides (organic xenobiotics) in ecosystems. Antisense DNA technology is very efficient eco-friendly platform against hemipteran insect pests [4], and also is moderately effective against lepidopterans [5].
References
[edit]- ^ Oberemok, Volodymyr Volodymyrovych; Laikova, Kateryna Volodymyrivna; Gninenko, Yuri Ivanovich; Zaitsev, Aleksei Sergeevich; Nyadar, Palmah Mutah; Adeyemi, Tajudeen Adesoji (2015-07-01). "A short history of insecticides". Journal of Plant Protection Research. 55 (3): 221–226. doi:10.1515/jppr-2015-0033. ISSN 1899-007X.
- ^ Oberemok, V.V. (2008). Method of elimination of phyllophagous insects from order Lepidoptera, Patent of Ukraine No 36445, Publ 27/10/2008, Bull 20
- ^ Boukouvala, Maria C.; Kavallieratos, Nickolas G.; Skourti, Anna; Pons, Xavier; Alonso, Carmen López; Eizaguirre, Matilde; Fernandez, Enrique Benavent; Solera, Elena Domínguez; Fita, Sergio; Bohinc, Tanja; Trdan, Stanislav; Agrafioti, Paraskevi; Athanassiou, Christos G. (2022-09-19). "Lymantria dispar (L.) (Lepidoptera: Erebidae): Current Status of Biology, Ecology, and Management in Europe with Notes from North America". Insects. 13 (9): 854. doi:10.3390/insects13090854. ISSN 2075-4450. PMC 9506003. PMID 36135555.
- ^ a b Oberemok, Volodymyr V.; Gal’chinsky, Nikita V.; Useinov, Refat Z.; Novikov, Ilya A.; Puzanova, Yelizaveta V.; Filatov, Roman I.; Kouakou, Nanan J.; Kouame, Kra F.; Kra, Kouadio D.; Laikova, Kateryna V. (May 2023). "Four Most Pathogenic Superfamilies of Insect Pests of Suborder Sternorrhyncha: Invisible Superplunderers of Plant Vitality". Insects. 14 (5): 462. doi:10.3390/insects14050462. ISSN 2075-4450. PMC 10231085. PMID 37233090.
- ^ a b Oberemok, Volodymyr V.; Laikova, Kateryna V.; Gal’chinsky, Nikita V.; Useinov, Refat Z.; Novikov, Ilya A.; Temirova, Zenure Z.; Shumskykh, Maksym N.; Krasnodubets, Alisa M.; Repetskaya, Anna I.; Dyadichev, Valeriy V.; Fomochkina, Iryna I.; Bessalova, Evgenia Y.; Makalish, Tatiana P.; Gninenko, Yuri I.; Kubyshkin, Anatoly V. (2019-04-17). "DNA insecticide developed from the Lymantria dispar 5.8S ribosomal RNA gene provides a novel biotechnology for plant protection". Scientific Reports. 9 (1): 6197. Bibcode:2019NatSR...9.6197O. doi:10.1038/s41598-019-42688-8. ISSN 2045-2322. PMC 6470133. PMID 30996277.
- ^ "Feasibility of Antisense Oligonucleotides as DNA Insecticides". TriLink BioTechnologies.
- ^ Mathew, Manju, et all (2021). "DNA INSECTICIDES: AN EMERGING TOOL IN PEST MANAGEMENT" (PDF). Agriallis. 4 (9): 29–35.
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