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EXTL2

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EXTL2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEXTL2, EXTR2, exostosin-like glycosyltransferase 2, exostosin like glycosyltransferase 2
External IDsOMIM: 602411; MGI: 1889574; HomoloGene: 1102; GeneCards: EXTL2; OMA:EXTL2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001033025
NM_001261440
NM_001261441
NM_001261442
NM_001439

NM_001163514
NM_001163515
NM_021388

RefSeq (protein)

NP_001028197
NP_001248369
NP_001248370
NP_001248371
NP_001430

NP_001156986
NP_001156987
NP_067363

Location (UCSC)Chr 1: 100.87 – 100.9 MbChr 3: 115.8 – 115.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Exostosin-like 2 is a protein that in humans is encoded by the EXTL2 gene.[5][6][7] EXTL2 Glycosyltransferase is required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. (https://www.phosphosite.org/overviewExecuteAction?id=5020882)

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162694Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027963Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wuyts W, Van Hul W, Hendrickx J, Speleman F, Wauters J, De Boulle K, Van Roy N, Van Agtmael T, Bossuyt P, Willems PJ (Mar 1998). "Identification and characterization of a novel member of the EXT gene family, EXTL2". Eur J Hum Genet. 5 (6): 382–9. doi:10.1159/000484796. PMID 9450183.
  6. ^ Sobhany M, Dong J, Negishi M (Jun 2005). "Two-step mechanism that determines the donor binding specificity of human UDP-N-acetylhexosaminyltransferase". J Biol Chem. 280 (25): 23441–5. doi:10.1074/jbc.M413379200. PMID 15831490.
  7. ^ "Entrez Gene: EXTL2 exostoses (multiple)-like 2".

Further reading

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  • PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Exostosin-like 2