FSCN3

FSCN3
Identifiers
Aliases	FSCN3, fascin actin-bundling protein 3
External IDs	OMIM: 615800; MGI: 1890386; HomoloGene: 10475; GeneCards: FSCN3; OMA:FSCN3 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	127,602,144 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	28,438,621 bp
RNA expression pattern
	Top expressed in
	sperm; ; left testis; ; right testis; ; testicle; ; granulocyte; ; gonad; ; muscle of thigh; ; cerebellar cortex; ; cerebellar hemisphere; ; prefrontal cortex;
	Top expressed in
	seminiferous tubule; ; spermatid; ; blastocyst; ; embryo; ; spermatocyte; ; embryo; ; upper arm; ; medial ganglionic eminence; ; triceps brachii muscle; ; yolk sac;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein-macromolecule adaptor activity; actin binding; actin filament binding;
Cellular component	cytoskeleton; actin cytoskeleton; cytoplasm; filamentous actin; ruffle; microvillus; lamellipodium; filopodium; growth cone; cell projection membrane;
Biological process	spermatid development; actin filament organization; anatomical structure morphogenesis; establishment or maintenance of cell polarity; actin filament bundle assembly; cell migration;
	Sources:Amigo / QuickGO
Orthologs
	29999
	56223
	ENSG00000106328
	ENSMUSG00000029707
	Q9NQT6
	Q9QXW4
	NM_020369
	NM_019569
	NP_065102
	NP_062515
	Wikidata
View/Edit Human	View/Edit Mouse

Fascin-3 also known as testis fascin is a protein that in humans is encoded by the FSCN3 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000106328 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029707 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: fascin homolog 3".
^ Tubb B, Mulholland DJ, Vogl W, Lan ZJ, Niederberger C, Cooney A, Bryan J (April 2002). "Testis fascin (FSCN3): a novel paralog of the actin-bundling protein fascin expressed specifically in the elongate spermatid head". Exp. Cell Res. 275 (1): 92–109. doi:10.1006/excr.2002.5486. PMID 11925108.

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Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Tubb BE, Bardien-Kruger S, Kashork CD, et al. (2000). "Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes". Genomics. 65 (2): 146–56. doi:10.1006/geno.2000.6156. PMID 10783262.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

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