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Protein-coding gene in the species Homo sapiens
Golgin subfamily A member 3 is a protein that in humans is encoded by the GOLGA3 gene .[ 5] [ 6] [ 7]
The Golgi apparatus , which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis .
This gene encodes a member of the golgin family of proteins which are localized to the Golgi. Its encoded protein has been postulated to play a role in nuclear transport and Golgi apparatus localization. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined.[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000090615 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029502 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Fritzler MJ, Hamel JC, Ochs RL, Chan EK (Jul 1993). "Molecular characterization of two human autoantigens: unique cDNAs encoding 95- and 160-kD proteins of a putative family in the Golgi complex" . J Exp Med . 178 (1): 49–62. doi :10.1084/jem.178.1.49 . PMC 2191081 PMID 8315394 . ^ Maag RS, Mancini M, Rosen A, Machamer CE (Jun 2005). "Caspase-resistant Golgin-160 Disrupts Apoptosis Induced by Secretory Pathway Stress and Ligation of Death Receptors" . Mol Biol Cell . 16 (6): 3019–27. doi :10.1091/mbc.E04-11-0971 . PMC 1142444 PMID 15829563 . ^ a b "Entrez Gene: GOLGA3 golgi autoantigen, golgin subfamily a, 3" .
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