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HLA-DMB

From Wikipedia, the free encyclopedia

HLA-DMB
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHLA-DMB, D6S221E, RING7, major histocompatibility complex, class II, DM beta
External IDsOMIM: 142856; MGI: 95922; HomoloGene: 68231; GeneCards: HLA-DMB; OMA:HLA-DMB - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002118

NM_010387

RefSeq (protein)

NP_002109

NP_034517

Location (UCSC)Chr 6: 32.93 – 32.94 MbChr 17: 34.37 – 34.38 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

HLA class II histocompatibility antigen, DM beta chain is a protein that in humans is encoded by the HLA-DMB gene.[5][6]

Function

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HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26–28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.[6]

Clinical significance

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HLA-DMB is upregulated in tumor tissue of Caucasian but not African patients. Its role in tumor immunology is undefined but has been shown to positively correlated with increased T-cell infiltration and improved prognosis in ovarian cancer. Differential immune processes mediated by HLA-DMB may contribute to the disparity in cancer outcome.[7]

References

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  1. ^ a b c ENSG00000226264, ENSG00000242574, ENSG00000239329, ENSG00000234154, ENSG00000242386, ENSG00000242092, ENSG00000241296 GRCh38: Ensembl release 89: ENSG00000241674, ENSG00000226264, ENSG00000242574, ENSG00000239329, ENSG00000234154, ENSG00000242386, ENSG00000242092, ENSG00000241296Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000079547Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kelly AP, Monaco JJ, Cho SG, Trowsdale J (Nov 1991). "A new human HLA class II-related locus, DM". Nature. 353 (6344): 571–3. Bibcode:1991Natur.353..571K. doi:10.1038/353571a0. PMID 1922365. S2CID 3065226.
  6. ^ a b "Entrez Gene: HLA-DMB major histocompatibility complex, class II, DM beta".
  7. ^ Kinseth MA, Jia Z, Rahmatpanah F, Sawyers A, Sutton M, Wang-Rodriguez J, Mercola D, McGuire KL (Jan 2014). "Expression differences between African American and Caucasian prostate cancer tissue reveals that stroma is the site of aggressive changes". International Journal of Cancer. 134 (1): 81–91. doi:10.1002/ijc.28326. PMC 3800217. PMID 23754304.

Further reading

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