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Karst Hoogsteen

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Karst Hoogsteen
Born1 October 1923
Died10 August 2015(2015-08-10) (aged 91)
NationalityDutch, American
Alma materUniversity of Groningen
Known forHoogsteen base pairs
Scientific career
Fields
InstitutionsCalifornia Institute of Technology, Merck Sharp and Dohme[1]
Thesis The crystal structure of trismethylsulfonylmethane-NH4  (May 1957[2])
Doctoral advisorPieter Terpstra[2]

Karst Hoogsteen (October 1, 1923 – August 10, 2015)[1] was a Dutch-born American biochemist famous for noting a new base-pairing form in DNA, now called Hoogsteen base pairs.[3] These base pairings intercede in the Watson–Crick base pairing, forging a base pair 'triplex'. The base pairs use the N7 nitrogen atom as the acceptor, rather than the N1 as observed in Watson-Crick base pairing. This leads to a twisted, non-linear arrangement.

References

[edit]
  1. ^ a b "Obituary for Dr. Karst Hoogsteen".
  2. ^ a b Karst Hoogsteen at Album Promotorum - Bibliotheek der Rijksuniversiteit Groningen.
  3. ^ Honig, Barry; Rohs, Remo (24 February 2011), "Biophysics: Flipping Watson and Crick", Nature, 470 (7335): 472–473, Bibcode:2011Natur.470..472H, doi:10.1038/470472a, PMID 21350476, S2CID 203458772.