Liranaftate
Appearance
![]() | |
Clinical data | |
---|---|
Trade names | Zefnart |
Other names | M-732; piritetrate |
Routes of administration | Topical |
ATC code | |
Legal status | |
Legal status |
|
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
KEGG | |
CompTox Dashboard (EPA) | |
Chemical and physical data | |
Formula | C18H20N2O2S |
Molar mass | 328.43 g·mol−1 |
Liranaftate (trade name Zefnart) is a topical antifungal drug.[1] It is used as a 2% cream used to treat tinea pedis (athlete's foot), tinea corporis (ringworm), and tinea cruris (jock itch).[2] It was approved for use in Japan in August 2000.[3][4]
Liranaftate works by inhibiting the fungal enzyme squalene epoxidase that is necessary for the fungus to synthesize sterols which are essential for cell membrane integrity.[5]
References
[edit]- ^ Koga H, Nanjoh Y, Makimura K, Tsuboi R (2009). "In vitro antifungal activities of luliconazole, a new topical imidazole". Medical Mycology. 47 (6): 640–7. doi:10.1080/13693780802541518. PMID 19115136.
- ^ "Torii Pharmaceutical to Launch Antifungal Agent for External Use, "ZEFNART SOLUTION 2%", in Japan" (Press release). Torii Pharmaceutical Co. Retrieved June 27, 2021.
- ^ "Liranaftate". ncats.io. Retrieved June 27, 2021.
- ^ "Liranaftate". Adis Insight. Retrieved June 27, 2021.
- ^ "Liranaftate". targetmol.com. Retrieved June 27, 2021.