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MAGED1

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MAGED1
Identifiers
AliasesMAGED1, DLXIN-1, NRAGE, MAGE family member D1
External IDsOMIM: 300224; MGI: 1930187; HomoloGene: 5077; GeneCards: MAGED1; OMA:MAGED1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001005332
NM_001005333
NM_006986

NM_019791

RefSeq (protein)

NP_001005332
NP_001005333
NP_008917

NP_062765

Location (UCSC)Chr X: 51.8 – 51.9 MbChr X: 93.58 – 93.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Melanoma-associated antigen D1 is a protein that in humans is encoded by the MAGED1 gene.[5][6]

Function

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This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. Three transcript variants encoding two different isoforms have been found for this gene.[6]

MAGED was found to be deleted in a group of children with an intellectual disability disorder caused by a Xp11.22 deletion.[7]

Maged1 plays a role in controlling the reward circuitry in the brain of mice that is responsible for addictive behaviors.[8] More recently, it has been shown to play a role in drug addiction through an epigenetic mechanism involving the monoubiquitination of H2A, which represses gene expression via interaction with the deubiquitinase USP7.[9]

Interactions

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MAGED1 has been shown to interact with UNC5A,[10] PJA1,[11] XIAP,[12] and USP7.[9]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000179222Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025151Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Põld M, Zhou J, Chen GL, Hall JM, Vescio RA, Berenson JR (Sep 1999). "Identification of a new, unorthodox member of the MAGE gene family". Genomics. 59 (2): 161–7. doi:10.1006/geno.1999.5870. PMID 10409427.
  6. ^ a b "Entrez Gene: MAGED1 melanoma antigen family D, 1".
  7. ^ Grau C, Starkovich M, Azamian MS, Xia F, Cheung SW, Evans P, et al. (2017). "Xp11.22 deletions encompassing CENPVL1, CENPVL2, MAGED1 and GSPT2 as a cause of syndromic X-linked intellectual disability". PLOS ONE. 12 (4): e0175962. Bibcode:2017PLoSO..1275962G. doi:10.1371/journal.pone.0175962. PMC 5393878. PMID 28414775.
  8. ^ De Backer JF, Monlezun S, Detraux B, Gazan A, Vanopdenbosch L, Cheron J, et al. (July 2018). "Deletion of Maged1 in mice abolishes locomotor and reinforcing effects of cocaine". EMBO Reports. 19 (9): e45089. doi:10.15252/embr.201745089. PMC 6123657. PMID 30002119.*Lay summary in: "A gene required for addictive behavior". ScienceDaily. July 12, 2018.
  9. ^ a b Cheron J, Beccari L, Hagué P, Icick R, Despontin C, Carusone T, et al. (December 2023). "USP7/Maged1-mediated H2A monoubiquitination in the paraventricular thalamus: an epigenetic mechanism involved in cocaine use disorder". Nature Communications. 14 (1): 8481. doi:10.1038/s41467-023-44120-2. PMC 10733359. PMID 38123574.
  10. ^ Williams ME, Strickland P, Watanabe K, Hinck L (May 2003). "UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE". J. Biol. Chem. 278 (19): 17483–90. doi:10.1074/jbc.M300415200. PMID 12598531.
  11. ^ Sasaki A, Masuda Y, Iwai K, Ikeda K, Watanabe K (Jun 2002). "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1". J. Biol. Chem. 277 (25): 22541–6. doi:10.1074/jbc.M109728200. PMID 11959851.
  12. ^ Jordan BW, Dinev D, LeMellay V, Troppmair J, Gotz R, Wixler L, et al. (Oct 2001). "Neurotrophin receptor-interacting mage homologue is an inducible inhibitor of apoptosis protein-interacting protein that augments cell death". J. Biol. Chem. 276 (43): 39985–9. doi:10.1074/jbc.C100171200. PMID 11546791.

Further reading

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