MT-7716

MT-7716
Names
	IUPAC name 2-[3-[1-[(1R)-1,2-dihydroacenaphthylen-1-yl]piperidin-4-yl]-2-oxobenzimidazol-1-yl]-N-methylacetamide
Identifiers
CAS Number	610323-32-5 (Free base); 1215859-92-9 (Hydrochloride);
PubChem CID	11464846;
CompTox Dashboard (EPA)	DTXSID70466750 ;
Properties
Chemical formula	C27H28N4O2
Molar mass	440.547 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

MT-7716 is an experimental opioid drug that could potentially be used in the treatment of alcohol addiction.

Mechanism of action

Unlike most opioids, MT-7716 does not appear to act through delta, kappa and mu opioid receptors, but instead is an agonist of the nociceptin receptor.^[1]

Alcohol addiction

A study has shown that MT-7716 was able to decrease alcohol self-administration and reduce alcohol withdrawal symptoms in rats.^[2]

Another study was also able to show similar results, in addition to demonstrating MT-7716's ability to suppress stress-induced alcohol seeking.^[3]

References

^ Kallupi, Marsida; Oleata, Christopher S.; Luu, George; Teshima, Koji; Ciccocioppo, Roberto; Roberto, Marisa (2014). "MT-7716, a novel selective nonpeptidergic NOP receptor agonist, effectively blocks ethanol-induced increase in GABAergic transmission in the rat central amygdala". Frontiers in Integrative Neuroscience. 8: 18. doi:10.3389/fnint.2014.00018. ISSN 1662-5145. PMC 3927450. PMID 24600360.
^ Ciccocioppo, Roberto; Stopponi, Serena; Economidou, Daina; Kuriyama, Makoto; Kinoshita, Hiroshi; Heilig, Markus; Roberto, Marisa; Weiss, Friedbert; Teshima, Koji (April 2014). "Chronic treatment with novel brain-penetrating selective NOP receptor agonist MT-7716 reduces alcohol drinking and seeking in the rat". Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology. 39 (11): 2601–2610. doi:10.1038/npp.2014.113. ISSN 1740-634X. PMC 4207340. PMID 24863033.
^ de Guglielmo, Giordano; Martin-Fardon, Rémi; Teshima, Koji; Ciccocioppo, Roberto; Weiss, Friedbert (July 2015). "MT-7716, a potent NOP receptor agonist, preferentially reduces ethanol seeking and reinforcement in post-dependent rats". Addiction Biology. 20 (4): 643–651. doi:10.1111/adb.12157. ISSN 1355-6215. PMC 4268094. PMID 24930632.

[1] Kallupi, Marsida; Oleata, Christopher S.; Luu, George; Teshima, Koji; Ciccocioppo, Roberto; Roberto, Marisa (2014). "MT-7716, a novel selective nonpeptidergic NOP receptor agonist, effectively blocks ethanol-induced increase in GABAergic transmission in the rat central amygdala". Frontiers in Integrative Neuroscience. 8: 18. doi:10.3389/fnint.2014.00018. ISSN 1662-5145. PMC 3927450. PMID 24600360.

[2] Ciccocioppo, Roberto; Stopponi, Serena; Economidou, Daina; Kuriyama, Makoto; Kinoshita, Hiroshi; Heilig, Markus; Roberto, Marisa; Weiss, Friedbert; Teshima, Koji (April 2014). "Chronic treatment with novel brain-penetrating selective NOP receptor agonist MT-7716 reduces alcohol drinking and seeking in the rat". Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology. 39 (11): 2601–2610. doi:10.1038/npp.2014.113. ISSN 1740-634X. PMC 4207340. PMID 24863033.

[3] Guglielmo, Giordano; Martin-Fardon, Rémi; Teshima, Koji; Ciccocioppo, Roberto; Weiss, Friedbert (July 2015). "MT-7716, a potent NOP receptor agonist, preferentially reduces ethanol seeking and reinforcement in post-dependent rats". Addiction Biology. 20 (4): 643–651. doi:10.1111/adb.12157. ISSN 1355-6215. PMC 4268094. PMID 24930632.

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