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Mannitol 2-dehydrogenase (NADP+)

From Wikipedia, the free encyclopedia
mannitol 2-dehydrogenase (NADP+)
Identifiers
EC no.1.1.1.138
CAS no.37250-68-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a mannitol 2-dehydrogenase (NADP+) (EC 1.1.1.138) is an enzyme that catalyzes the chemical reaction

D-mannitol + NADP+ D-fructose + NADPH + H+

Thus, the two substrates of this enzyme are D-mannitol and NADP+, whereas its 3 products are D-fructose, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-mannitol:NADP+ 2-oxidoreductase. This enzyme is also called mannitol 2-dehydrogenase (NADP+). This enzyme participates in fructose and mannose metabolism.

Structural studies

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As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1H5Q.

References

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  • Edmundowicz JM, Wriston JC (1963). "Mannitol dehydrogenase from Agaricus campestris". J. Biol. Chem. 238 (11): 3539–41. doi:10.1016/S0021-9258(19)75304-6. PMID 14109183.
  • Strobel GA; Kosuge T (1965). "Polyol metabolism in Diplodia viticola Desm". Arch. Biochem. Biophys. 109 (3): 622–626. doi:10.1016/0003-9861(65)90409-1. PMID 14320506.