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NDRG2

From Wikipedia, the free encyclopedia
NDRG2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNDRG2, SYLD, NDRG family member 2
External IDsOMIM: 605272; MGI: 1352498; HomoloGene: 22785; GeneCards: NDRG2; OMA:NDRG2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001145959
NM_013864

RefSeq (protein)
Location (UCSC)Chr 14: 21.02 – 21.07 MbChr 14: 51.91 – 51.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein NDRG2 is a protein that in humans is encoded by the NDRG2 gene (NMYC downstream-regulated gene 2).[5][6]

Function

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This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma and aggressive meningioma carcinogenesis (via cell proliferation[7]).[8] Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000165795Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004558Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kalaydjieva L, Gresham D, Gooding R, Heather L, Baas F, de Jonge R, Blechschmidt K, Angelicheva D, Chandler D, Worsley P, Rosenthal A, King RH, Thomas PK (Aug 2000). "N-myc downstream-regulated gene 1 is mutated in hereditary motor and sensory neuropathy-Lom". Am J Hum Genet. 67 (1): 47–58. doi:10.1086/302978. PMC 1287101. PMID 10831399.
  6. ^ a b "Entrez Gene: NDRG2 NDRG family member 2".
  7. ^ Deng Y, Yao L, Chau L, Ng SS, Peng Y, Liu X, Au WS, Wang J, Li F, Ji S, Han H, Nie X, Li Q, Kung HF, Leung SY, Lin MC (September 2003). "N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation". Int. J. Cancer. 106 (3): 342–7. doi:10.1002/ijc.11228. PMID 12845671.
  8. ^ Lusis EA, Watson MA, Chicoine MR, Lyman M, Roerig P, Reifenberger G, Gutmann DH, Perry A (August 2005). "Integrative genomic analysis identifies NDRG2 as a candidate tumor suppressor gene frequently inactivated in clinically aggressive meningioma". Cancer Res. 65 (16): 7121–6. doi:10.1158/0008-5472.CAN-05-0043. PMID 16103061.

Further reading

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