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Ornithine cyclodeaminase

From Wikipedia, the free encyclopedia
ornithine cyclodeaminase
Identifiers
EC no.4.3.1.12
CAS no.9054-76-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

The enzyme ornithine cyclodeaminase (EC 4.3.1.12) catalyzes the chemical reaction

L-ornithine L-proline + NH4+

This enzyme belongs to the family of lyases, specifically ammonia lyases, which cleave carbon-nitrogen bonds. The systematic name of this enzyme class is Lornithine ammonia-lyase (cyclizing; L-proline-forming). Other names in common use include ornithine cyclase, ornithine cyclase (deaminating), and L-ornithine ammonia-lyase (cyclizing). This enzyme participates in arginine and proline biosynthesis. It employs one cofactor, NAD+.

Structural studies

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As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1U7H and 1X7D.

References

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