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POLDIP3

From Wikipedia, the free encyclopedia

POLDIP3
Identifiers
AliasesPOLDIP3, PDIP46, SKAR, polymerase (DNA) delta interacting protein 3, DNA polymerase delta interacting protein 3, PDIP3
External IDsOMIM: 611520; MGI: 1921076; HomoloGene: 13007; GeneCards: POLDIP3; OMA:POLDIP3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001278657
NM_032311
NM_178136
NM_001363052

NM_178627
NM_001347082

RefSeq (protein)

NP_001265586
NP_115687
NP_835237
NP_001349981

NP_001334011
NP_848742

Location (UCSC)Chr 22: 42.58 – 42.61 MbChr 15: 83.01 – 83.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Polymerase delta-interacting protein 3 is an enzyme that in humans is encoded by the POLDIP3 gene.[5][6]

This gene encodes a protein that interacts with the DNA polymerase delta p50 subunit. This protein is a specific target of S6 kinase 1 and regulates cell growth. Two transcript variants that encode different protein isoforms have been identified.[6]

Interactions

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POLDIP3 has been shown to interact with P70-S6 Kinase 1.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100227Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041815Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Liu L, Rodriguez-Belmonte EM, Mazloum N, Xie B, Lee MY (Mar 2003). "Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen". J Biol Chem. 278 (12): 10041–7. doi:10.1074/jbc.M208694200. PMID 12522211.
  6. ^ a b "Entrez Gene: POLDIP3 polymerase (DNA-directed), delta interacting protein 3".
  7. ^ Richardson CJ, Bröenstrup Mark, Fingar Diane C, Jülich Kristina, Ballif Bryan A, Gygi Steven, Blenis John (Sep 2004). "SKAR is a specific target of S6 kinase 1 in cell growth control". Curr. Biol. 14 (17). England: 1540–9. Bibcode:2004CBio...14.1540R. doi:10.1016/j.cub.2004.08.061. ISSN 0960-9822. PMID 15341740.

Further reading

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