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Phosphopantothenoylcysteine decarboxylase

From Wikipedia, the free encyclopedia
phosphopantothenoylcysteine decarboxylase
Identifiers
EC no.4.1.1.36
CAS no.9024-69-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

The enzyme phosphopantothenoylcysteine decarboxylase (EC 4.1.1.36) catalyzes the chemical reaction

N-[(R)-4'-phosphopantothenoyl]-L-cysteine pantotheine 4'-phosphate + CO2

This enzyme belongs to the family of lyases, to be specific the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase (pantotheine-4'-phosphate-forming). This enzyme participates in coenzyme A (CoA) biosynthesis from pantothenic acid.

Structural studies

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As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1MVL, 1MVN, and 1QZU.

References

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  • Brown GM (1958). "Requirement of cytidine triphosphate for the biosynthesis of phosphopantetheine". J. Am. Chem. Soc. 80 (12): 3161. doi:10.1021/ja01545a062.
  • Brown GM (February 1959). "The metabolism of pantothenic acid". The Journal of Biological Chemistry. 234 (2): 370–8. PMID 13630913.