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The Shuttle–Mir program (Russian: Программа «Мир»–«Шаттл») was a collaborative space program between Russia and the United States that involved American Space Shuttles visiting the Russian space station Mir, Russian cosmonauts flying on the Shuttle, and an American astronaut flying aboard a Soyuz spacecraft to allow American astronauts to engage in long-duration expeditions aboard Mir.

The project, sometimes called "Phase One", was intended to allow the United States to learn from Russian experience with long-duration spaceflight and to foster a spirit of cooperation between the two nations and their space agencies, the National Aeronautics and Space Administration (NASA) and the Russian Space Agency (PKA). The project helped to prepare the way for further cooperative space ventures; specifically, "Phase Two" of the joint project, the construction of the International Space Station (ISS). The program was announced in 1993, the first mission started in 1994 and the project continued until its scheduled completion in 1998. Eleven Space Shuttle missions, a joint Soyuz flight and almost 1,000 cumulative days in space for American astronauts occurred over the course of seven long-duration expeditions. In addition to Space Shuttle launches to Mir the United States also fully funded and equipped with scientific equipment the Spektr module (launched in 1995) and the Priroda module (launched in 1996), making them de facto U.S. modules during the duration of the Shuttle-Mir program.

During the four-year program, many firsts in spaceflight were achieved by the two nations, including the first American astronaut to launch aboard a Soyuz spacecraft, the largest spacecraft ever to have been assembled at that time in history, and the first American spacewalk using a Russian Orlan spacesuit.