S-(2-Aminoethyl)isothiuronium bromide hydrobromide
Appearance
![]() | |
Names | |
---|---|
IUPAC name
2-aminoethyl carbamimidothioate;dihydrobromide
| |
Other names
beta-Aminoethylisothiuronium bromide; beta-Aminoethyl isothiourea; 2-(2-Aminoethyl)-2-thiopseudourea dihydrobromide; AET; AI3-23427; Antirad; Antiradon; Ixecur; Pseudourea, (2-aminoethyl)-2-thio-, dihydrobromide; S-(2-Aminoaethyl)isothiuronium dibromid; S-(2-Aminoethyl)isothiuronium dibromide; S-(2-Aminoethyl)pseudothiourea dihydrobromide; S-2-Aminoethylisothiouronium bromide hydrobromide; Surrectan;
| |
Identifiers | |
3D model (JSmol)
|
|
ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.000.234 |
EC Number |
|
KEGG | |
PubChem CID
|
|
UNII | |
CompTox Dashboard (EPA)
|
|
| |
| |
Properties | |
C3H11Br2N3S | |
Molar mass | 281.015 g/mol |
Hazards | |
GHS labelling:[1] | |
![]() | |
Warning | |
H302, H315, H319, H335 | |
P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, P501 | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|
S-(2-Aminoethyl)isothiourea dihydrobromide,[2] commonly knwn as AET, is a isothiouronium-group-containing reducing agent with textbook uses as a disulfide reducing agent. Though it does not have a free thiol group (-SH) like 2-mercaptoethanol and dithiothreitol (DTT), it reacts with water to decompose transiently into thiol intermediates that acts on disulfide in a manner to these containing free -SH groups.
Applications
[edit]One application of AET is in hematology where red cells are treated with AET to create PNH-like cells.[3]
References
[edit]- ^ "2-(2-Aminoethyl)isothiourea dihydrobromide". Pubchem.ncbi.NLM.nih.gov.
- ^ "2-(2-Aminoethyl)isothiourea dihydrobromide". Pubchem.
- ^ Sirchia, G (1969). "In-Vitro Lysis of AET-Treated Normal Red Cells (PNH-like Cells) by Normal and Cirrhotic Sera". British Journal of Haematology. 17 (3): 245–249. doi:10.1111/j.1365-2141.1969.tb01369.x. PMID 4979897. S2CID 46358253.