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Zinc transporter ZIP1

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(Redirected from SLC39A1)
SLC39A1
Identifiers
AliasesSLC39A1, ZIP1, ZIRTL, solute carrier family 39 member 1
External IDsOMIM: 604740; MGI: 1353474; HomoloGene: 40906; GeneCards: SLC39A1; OMA:SLC39A1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_013901

RefSeq (protein)

NP_038929

Location (UCSC)Chr 1: 153.96 – 153.97 MbChr 3: 90.16 – 90.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc transporter ZIP1 is a protein that in humans is encoded by the SLC39A1 gene.[5][6][7]

The protein ZIP1 is responsible for the active transport of zinc into prostate cells. In many prostate cancers SLC39A1 is silenced causing prostate cancer cells to be low in zinc.[8]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143570Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052310Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lioumi M, Ferguson CA, Sharpe PT, Freeman T, Marenholz I, Mischke D, Heizmann C, Ragoussis J (Feb 2000). "Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex". Genomics. 62 (2): 272–80. doi:10.1006/geno.1999.5993. PMID 10610721.
  6. ^ Gaither LA, Eide DJ (Mar 2000). "Functional expression of the human hZIP2 zinc transporter". J Biol Chem. 275 (8): 5560–4. doi:10.1074/jbc.275.8.5560. PMID 10681536.
  7. ^ "Entrez Gene: SLC39A1 solute carrier family 39 (zinc transporter), member 1".
  8. ^ Costello LC, Franklin RB (2006). "The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots". Mol. Cancer. 5: 17. doi:10.1186/1476-4598-5-17. PMC 1481516. PMID 16700911.

Further reading

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