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Sialidase-2

From Wikipedia, the free encyclopedia

NEU2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNEU2, SIAL2, neuraminidase 2 (cytosolic sialidase), neuraminidase 2
External IDsOMIM: 605528; MGI: 1344417; HomoloGene: 3927; GeneCards: NEU2; OMA:NEU2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005383

NM_001160163
NM_001160164
NM_001160165
NM_015750

RefSeq (protein)

NP_005374

NP_001153635
NP_001153636
NP_001153637
NP_056565

Location (UCSC)Chr 2: 233.03 – 233.04 MbChr 1: 87.44 – 87.53 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sialidase-2 is an enzyme that in humans is encoded by the NEU2 gene.[5][6][7]

This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. Expression studies in COS-7 cells confirmed that this gene encodes a functional sialidase. Its cytosolic localization was demonstrated by cell fractionation experiments.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115488Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000079434Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Monti E, Preti A, Rossi E, Ballabio A, Borsani G (Jun 1999). "Cloning and characterization of NEU2, a human gene homologous to rodent soluble sialidases". Genomics. 57 (1): 137–143. doi:10.1006/geno.1999.5749. PMID 10191093.
  6. ^ Tringali C, Papini N, Fusi P, Croci G, Borsani G, Preti A, Tortora P, Tettamanti G, Venerando B, Monti E (Jan 2004). "Properties of recombinant human cytosolic sialidase HsNEU2. The enzyme hydrolyzes monomerically dispersed GM1 ganglioside molecules". J Biol Chem. 279 (5): 3169–3179. doi:10.1074/jbc.M308381200. PMID 14613940.
  7. ^ a b "Entrez Gene: NEU2 sialidase 2 (cytosolic sialidase)".

Further reading

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[edit]
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Sialidase-2