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TAF1A

From Wikipedia, the free encyclopedia
TAF1A
Identifiers
AliasesTAF1A, MGC:17061, RAFI48, SL1, TAFI48, TATA-box binding protein associated factor, RNA polymerase I subunit A
External IDsOMIM: 604903; MGI: 109578; HomoloGene: 4155; GeneCards: TAF1A; OMA:TAF1A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001201536
NM_005681
NM_139352

NM_001277957
NM_001277958
NM_001277959
NM_021466

RefSeq (protein)

NP_001188465
NP_005672
NP_647603

NP_001264886
NP_001264887
NP_001264888
NP_067441

Location (UCSC)Chr 1: 222.56 – 222.59 MbChr 1: 183.17 – 183.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

TATA box-binding protein-associated factor RNA polymerase I subunit A is an enzyme that in humans is encoded by the TAF1A gene.[5][6]

Function

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Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as selective factor 1 (SL1), binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the smallest SL1-specific TAF. Two transcripts encoding different isoforms have been identified.[6]

Interactions

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TAF1A has been shown to interact with Acidic leucine-rich nuclear phosphoprotein 32 family member A[7] and Protein SET.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143498Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000072258Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Comai L, Zomerdijk JC, Beckmann H, Zhou S, Admon A, Tjian R (December 1994). "Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits". Science. 266 (5193): 1966–72. Bibcode:1994Sci...266.1966C. doi:10.1126/science.7801123. PMID 7801123.
  6. ^ a b "Entrez Gene: TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa".
  7. ^ a b Seo SB, McNamara P, Heo S, Turner A, Lane WS, Chakravarti D (January 2001). "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein". Cell. 104 (1): 119–30. doi:10.1016/S0092-8674(01)00196-9. PMID 11163245. S2CID 11144887.

Further reading

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