Jump to content

TRA2A

From Wikipedia, the free encyclopedia
TRA2A
Identifiers
AliasesTRA2A, AWMS1, HSU53209, transformer 2 alpha homolog
External IDsOMIM: 602718; MGI: 1933972; HomoloGene: 40866; GeneCards: TRA2A; OMA:TRA2A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_198102
NM_001347209
NM_001362188

RefSeq (protein)

n/a

Location (UCSC)Chr 7: 23.5 – 23.53 MbChr 6: 49.22 – 49.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transformer-2 protein homolog alpha is a protein that in humans is encoded by the TRA2A gene.[5][6][7]

This gene is a member of the transformer 2 homolog family and encodes a protein with two RS domains and an RRM (RNA recognition motif) domain. This phosphorylated nuclear protein binds to specific RNA sequences and plays a role in the regulation of pre-mRNA splicing. Several alternatively spliced transcript variants of this gene have been described; however, the full-length nature of some of these variants has not been determined.[7]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164548Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029817Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Dauwalder B, Amaya-Manzanares F, Mattox W (Oct 1996). "A human homologue of the Drosophila sex determination factor transformer-2 has conserved splicing regulatory functions". Proc Natl Acad Sci U S A. 93 (17): 9004–9. Bibcode:1996PNAS...93.9004D. doi:10.1073/pnas.93.17.9004. PMC 38585. PMID 8799144.
  6. ^ Tacke R, Tohyama M, Ogawa S, Manley JL (May 1998). "Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing". Cell. 93 (1): 139–48. doi:10.1016/S0092-8674(00)81153-8. PMID 9546399. S2CID 15384749.
  7. ^ a b "Entrez Gene: TRA2A transformer-2 alpha".

Further reading

[edit]