Talk:Precursor mRNA

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I think this should be a redirect to "mRNA" the information is redundant Jasoninkid 00:48, 11 December 2006 (UTC)[reply]

Is hnRNA really a more appropriate name? I thought pre-mRNA was more commonly used, and more descriptive than yet another xyzRNA abbreviation. If there are semantic differences or reasons to choose one name over the other, perhaps it could be mentioned in the article? kzm 10:59, 13 November 2007 (UTC)[reply]

Agreed. hnRNA was the earliest term and then it was shown that the bulk of it ends up as mRNA. But I don't know that it has been shown that *all* hnRNA ends up as mRNA (i.e. is pre-mRNA) and without that proof, the identification of the terms, although commonly done, isn't 100% accurate. So I tried to rearrange the section to reflect this nuance.

Netrapt (talk) —Preceding undated comment added 07:29, 11 April 2009 (UTC).[reply]

I am considering developing this page further as part of an educational assignment in Fall of 2013. If someone else is also working on this, please send me a message and let me know soon, so we donʼt duplicate initial efforts in page development. Kohw 10:00, 6 October 2013 (UTC) — Preceding unsigned comment added by Kohw (talk • contribs)

Possible suggestion to the article

This article provides information on explanation of precursor mRNA and how precursor mRNA transcript leads to mature mRNA through processing. However, this article could be improved with more informations added. For example, more detailed information on how precursor mRNA becomes mature mRNA through processing, which can be seen in the bookshelf of NCBI site (on text The Cell: A Molecular Approach. 2nd edition). Full citation is: Cooper GM. The Cell: A Molecular Approach. 2nd edition. Sunderland (MA): Sinauer Associates; 2000. RNA Processing and Turnover. Available from: http://www.ncbi.nlm.nih.gov/books/NBK9864/) The information provided here provides pictures for better understanding and details on RNA processing in eukaryotes as well as prokaryotes and on turnover. In addition, more details regarding processing of precursor mRNA could be added. For example, information regarding the effects of 5' cap and poly A tail addition during processing could be included (how do they effect mature mRNA and proteins encoded later). Further, more details on splicing could provide better understanding of the bigger picture of the process to encode protein from transcription to processing to translation. Details on how alternative nRNA splicing could affect mature mRNA and protein isoforms, on the role of splicing enhancers, and on recognition factors could be added to provide a more clear explanation on the bigger picture as well as importance of the process of turning precursor mRNA into mature mRNA. Furthermore, informations on experiments involving precursor mRNA could possibly be added to show what factors can interfere with processing of precursor mRNA into mature mRNA. For example, a research article on PubMed that is provided by NCBI site shows that FUra could lead to cell death by inhibiting mRNA processing. The full citation is: Will CL, Dolnick BJ. 5-Fluorouracil inhibits dihydrofolate reductase precursor mRNA processing and/or nuclear mRNA stability in methotrexate-resistant KB cells. J Biol Chem. 1989 Dec 15;264(35):21413-21. PubMed PMID: 2592384. With some more information added, this article would provide readers with better understanding on this subject! Kohw 03:21, 7 October 2013 (UTC) — Preceding unsigned comment added by Kohw (talk • contribs)