Talk:Rexed laminae
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Dorsal horn circuitry
[edit]The dorsal horn is not a simple relay station, but a site of significantly complex signal processing.[1] The majority of neurones in laminae-I-III are excititatory or inhibitory interneurones.[2] There are a large number of different circuit motifs that have been found to involve specific types of dorsal horn interneurone, and functions involved in signal processing have been inferred from this. Glycinergic neurones compose about 90% of the inhibitory interneurone in deeper layers of the dorsal horn, whereas they only make up 20% of the inhibitory neurone population in laminae I & II. Parvalbumin-countaining neurones in lamina II, which utilise glycine, have been found to receive input from primary sensory afferents and provide presynaptic input to these terminals, allowing feedforward inhibition and winner-take-all computation. It has been suggested that they play a role in both the refinement information relating to tactile touch, and gating of tactile information being processed as pain in conditions such as allodynia.[3] B5-I interneurones play an important role in the processing of itch sensation, and can suppress itch through the action of dynorphin on delta opioid receptors, or cause fast relief from itch through the presence of competing somatosensory stimulation, for example scratching.[4]
- Moved this info from page - more relevant to posterior grey column and the refs to laminae are related to mice and rat studies.--Iztwoz (talk) 11:35, 2 June 2018 (UTC)
References
- ^ Benarroch EE (March 2016). "Dorsal horn circuitry: Complexity and implications for mechanisms of neuropathic pain". Neurology. 86 (11): 1060–9. doi:10.1212/WNL.0000000000002478. PMID 26888981.
- ^ Todd AJ, Sullivan AC (June 1990). "Light microscope study of the coexistence of GABA-like and glycine-like immunoreactivities in the spinal cord of the rat". The Journal of Comparative Neurology. 296 (3): 496–505. doi:10.1002/cne.902960312. PMID 2358549.
- ^ Hughes DI, Sikander S, Kinnon CM, Boyle KA, Watanabe M, Callister RJ, Graham BA (August 2012). "Morphological, neurochemical and electrophysiological features of parvalbumin-expressing cells: a likely source of axo-axonic inputs in the mouse spinal dorsal horn". The Journal of Physiology. 590 (16): 3927–51. doi:10.1113/jphysiol.2012.235655. PMC 3476641. PMID 22674718.
- ^ Kardon AP, Polgár E, Hachisuka J, Snyder LM, Cameron D, Savage S, Cai X, Karnup S, Fan CR, Hemenway GM, Bernard CS, Schwartz ES, Nagase H, Schwarzer C, Watanabe M, Furuta T, Kaneko T, Koerber HR, Todd AJ, Ross SE (May 2014). "Dynorphin acts as a neuromodulator to inhibit itch in the dorsal horn of the spinal cord". Neuron. 82 (3): 573–86. doi:10.1016/j.neuron.2014.02.046. PMID 24726382.