Template:1921 American League standings
| Team | W | L | Pct. | GB | Home | Road |
|---|---|---|---|---|---|---|
| New York Yankees | 98 | 55 | .641 | — | 53–25 | 45–30 |
| Cleveland Indians | 94 | 60 | .610 | 4½ | 51–26 | 43–34 |
| St. Louis Browns | 81 | 73 | .526 | 17½ | 43–34 | 38–39 |
| Washington Senators | 80 | 73 | .523 | 18 | 46–30 | 34–43 |
| Boston Red Sox | 75 | 79 | .487 | 23½ | 41–36 | 34–43 |
| Detroit Tigers | 71 | 82 | .464 | 27 | 37–40 | 34–42 |
| Chicago White Sox | 62 | 92 | .403 | 36½ | 37–40 | 25–52 |
| Philadelphia Athletics | 53 | 100 | .346 | 45 | 28–47 | 25–53 |