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Translin-associated factor X

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TSNAX
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTSNAX, TRAX, translin-associated factor X, translin associated factor X, C3PO
External IDsOMIM: 602964; MGI: 1855672; HomoloGene: 4374; GeneCards: TSNAX; OMA:TSNAX - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005999

NM_016909

RefSeq (protein)

NP_005990

NP_058605

Location (UCSC)Chr 1: 231.53 – 231.57 MbChr 8: 125.74 – 125.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Translin-associated protein X (abbr. TSNAX or TRAX) is a protein that in humans is encoded by the TSNAX gene.[5][6]

Function

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This gene encodes a protein which specifically interacts with translin, a DNA-binding protein that binds consensus sequences at breakpoint junctions of chromosomal translocations. The encoded protein contains bipartite nuclear targeting sequences that may provide nuclear transport for translin, which lacks any nuclear targeting motifs.[6] Both TSNAX and translin form the C3PO complex which facilitates endonucleolytic cleavage of the passenger strand during microRNA loading into the RNA-induced silencing complex (RISC).[7]

Interactions

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TSNAX has been shown to interact with C1D.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116918Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000056820Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Aoki K, Ishida R, Kasai M (Jan 1997). "Isolation and characterization of a cDNA encoding a Translin-like protein, TRAX". FEBS Letters. 401 (2–3): 109–12. doi:10.1016/S0014-5793(96)01444-5. PMID 9013868. S2CID 46704829.
  6. ^ a b "Entrez Gene: TSNAX translin-associated factor X".
  7. ^ Ha M, Kim VN (Aug 2014). "Regulation of microRNA biogenesis". Nature Reviews Molecular Cell Biology. 15 (8): 509–24. doi:10.1038/nrm3838. PMID 25027649. S2CID 205495632.
  8. ^ Erdemir T, Bilican B, Oncel D, Goding CR, Yavuzer U (Jan 2002). "DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX)". Journal of Cell Science. 115 (Pt 1): 207–16. doi:10.1242/jcs.115.1.207. hdl:11693/24740. PMID 11801738.

Further reading

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  • Overview of all the structural information available in the PDB for UniProt: Q99598 (Translin-associated protein X) at the PDBe-KB.