User talk:50.201.195.170/Ivermectin in COVID-19 pandemic RFC draft
Prevention RFC - Does relative evidence strength justify inclusion of ivermectin (I-MASK) in the prevention section over or in addition to hand washing and/or social distancing?
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Does relative evidence strength justify inclusion of ivermectin (I-MASK) in the prevention section of COVID-19 pandemic over or in addition to hand washing and/or social distancing?
Initial comment:
Leaving it out violates WP:UNDUE (it goes both ways. Many qualified experts are (cautiously but WP:Verifiably) calling it a game changer in numerous publications.
So as of mid-November, 2020, we have summaries, review articles (https://osf.io/wx3zn), by coalitions of independent, leading critical care doctors, scientists and independent brief reviews of reviews
Similar reviews with only minor variations.
When looking at recent (last 3 months) publications, I'm seeing WP:Verifiable consensus. While there's plenty of OLD credible critics of ivermectin, what's recent and worth mentioning on the critical side?
“ | Q: Should I take ivermectin to prevent or treat COVID-19?
A: No. |
” |
— FDA, on 5/1/2020 |
- There's the Surgisphere#COVID-19_misconduct scandal, but it's blown over. There's scientific consensus that the papers all failed science's and thus our WP:Verifiability criteria. And mentioning the scandal itself here would be WP:UNDUE.
- For balance, we have to dig further back. The best I can find is from an FDA Q&A on 5/1:
FDA has not yet published anything taking the peer reviewed, published study data into account that has been available for some time now, for ivermectin - both RCTs and cohort analysis. The newest citation in FDA's last publication on ivermectin was to an editorial, i.e. not a peer-reviewed paper; no disclosures section..
WIP. --~~~~
It does appear we have independent sources addressing the possibility, as the FLCCC group at first glance appears to be an association formed around the search for effective treatments and for months, they were NOT support of this treatment.[1]
But they were already strongly advocating for methylprednisolone and heparin (and to a lesser degree Vitamins B1, C, D, and Zinc), and their COI disclosure section is pristine, especially when compared with a lot of the other sources here implicitly deemed WP:Verifiable nonetheless.
EUREKA! Now we have a review article in the peer-reviewed literature! ... On the 6-month old version.--50.201.195.170 (talk) 19:57, 19 December 2020 (UTC)
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Initial additional comment:
list of review authors, with titles and affiliations of a review article
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( Review of the Emerging Evidence Supporting the Use of Ivermectin in the Prophylaxis and Treatment of COVID-19 by Front Line COVID-19 Critical Care Alliance )
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22 solid sources and growing
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(Note: Does not include or rely on discredited Surgisphere#COVID-19_misconduct reliant-study.) |
I've yet to search for reputable coverage in news media.
But already, in terms of weight of evidence, we have more evidence for ivermectin than hand washing, and about as much we do for face masks and social distancing. But these feature prominently, while ivermectin is not mentioned.
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Draft discussion
[edit]Again: Comments/suggestions welcome here as I polish; please no edits above, to avoid edit conflicts.--~~~~
RFC discussion
[edit]Not open yet.
- ^ Sentence 1: "In March 2020, an expert panel called the Front Line COVID-19 Critical Care Alliance (FLCCC) was created and led by Professor Paul E. Marik with the goal of continuously reviewing the rapidly emerging basic science, translational, and clinical data in order to gain insight into and to develop a treatment protocol for, COVID-19" [https://covid19criticalcare.com/wp-content/uploads/2020/11/FLCCC-Ivermectin-in-the-prophylaxis-and-treatment-of-COVID-19.pdf Review of the Emerging Evidence Supporting the Use of Ivermectin in the Prophylaxis and Treatment of COVID-19 ; Version 4; Nov. 19, 2020] by Pierre Kory, Associate Professor of Medicine, St. Luke’s Aurora Medical Center G. Umberto Meduri, Professor of Medicine, Univ. of Tennessee Health Science Center, Memphis Jose Iglesias, DO, Associate Professor of Medicine, Hackensack School of Medicine, Seton Hall Joseph Varon, MD, Professor of Medicine, University of Texas Health Science Center Keith Berkowitz, MD, Medical Director, Center for Balanced Health, New York Howard Kornfeld, MD, Diplomate in Emergency Medicine, Director, Recovery Without Walls Eivind Vinjevoll, MD, Critical Care and Emergency Department Chief, Volda, Norway Scott Mitchell, MRCS, Associate Specialist, Princess Elizabeth Hospital, Guernsey Fred Wagshul, MD, Medical Director, Lung Center of America, Dayton, Ohio Paul E. Marik, MD, Professor of Medicine, Eastern Virginia Medical School]