XIRP2

XIRP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4F14
Identifiers
Aliases	XIRP2, CMYA3, xin actin binding repeat containing 2
External IDs	OMIM: 609778; MGI: 2685198; HomoloGene: 19388; GeneCards: XIRP2; OMA:XIRP2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	167,259,753 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	67,356,959 bp
RNA expression pattern
	Top expressed in
	deltoid muscle; ; biceps brachii; ; Skeletal muscle tissue of rectus abdominis; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; tibialis anterior muscle; ; Skeletal muscle tissue of biceps brachii; ; myocardium of left ventricle; ; body of tongue; ; muscle of thigh;
	Top expressed in
	muscle of thigh; ; skeletal muscle tissue; ; ventricle; ; quadriceps femoris muscle; ; interventricular septum; ; left ventricle; ; zone of skin; ; esophagus; ; lip; ; superior frontal gyrus;
	More reference expression data
	n/a
Gene ontology
Molecular function	alpha-actinin binding; actin binding; actin filament binding;
Cellular component	cell junction; Z discdkac; stress fiber; focal adhesion; filamentous actin;
Biological process	heart development; cell-cell junction organization; cardiac muscle tissue morphogenesis; ventricular septum development; actin cytoskeleton organization; biological process;
	Sources:Amigo / QuickGO
Orthologs
	129446
	241431
	ENSG00000163092
	ENSMUSG00000027022
	A4UGR9
	Q4U4S6
	NM_152381; NM_001079810; NM_001199143; NM_001199144; NM_001199145
	NM_001024618; NM_001083919
	NP_001073278; NP_001186072; NP_001186073; NP_001186074; NP_689594
	NP_001019789; NP_001077388
	Wikidata
View/Edit Human	View/Edit Mouse

Xin actin-binding repeat-containing protein 2 is a protein that in humans is encoded by the XIRP2 gene.^[5]^[6]^[7]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163092 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027022 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Huang HT, Brand OM, Mathew M, Ignatiou C, Ewen EP, McCalmon SA, Naya FJ (Dec 2006). "Myomaxin is a novel transcriptional target of MEF2A that encodes a Xin-related alpha-actinin-interacting protein". J Biol Chem. 281 (51): 39370–9. doi:10.1074/jbc.M603244200. PMID 17046827.
^ Sinn HW, Balsamo J, Lilien J, Lin JJ (Aug 2002). "Localization of the novel Xin protein to the adherens junction complex in cardiac and skeletal muscle during development". Dev Dyn. 225 (1): 1–13. doi:10.1002/dvdy.10131. PMID 12203715. S2CID 23393425.
^ Pacholsky D, Vakeel P, Himmel M, Lowe T, Stradal T, Rottner K, Furst DO, van der Ven PF (Oct 2004). "Xin repeats define a novel actin-binding motif". J Cell Sci. 117 (Pt 22): 5257–68. doi:10.1242/jcs.01406. PMID 15454575. S2CID 5643531.
^ "Entrez Gene: CMYA3 cardiomyopathy associated 3".

Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Blasi F, Bacchelli E, Carone S, et al. (2006). "SLC25A12 and CMYA3 gene variants are not associated with autism in the IMGSAC multiplex family sample". Eur. J. Hum. Genet. 14 (1): 123–6. doi:10.1038/sj.ejhg.5201444. PMID 16205742.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Pan PW, Li K, Tuggle CK, et al. (2004). "Sequencing, tissue distribution and physical mapping of the porcine homologue of cardiomyopathy associated 3 (CMYA3)". Anim. Genet. 34 (6): 473–4. doi:10.1046/j.0268-9146.2003.01059.x. PMID 14687087.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163092 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027022 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid17046827-5] Huang HT, Brand OM, Mathew M, Ignatiou C, Ewen EP, McCalmon SA, Naya FJ (Dec 2006). "Myomaxin is a novel transcriptional target of MEF2A that encodes a Xin-related alpha-actinin-interacting protein". J Biol Chem. 281 (51): 39370–9. doi:10.1074/jbc.M603244200. PMID 17046827.

[pmid12203715-6] Sinn HW, Balsamo J, Lilien J, Lin JJ (Aug 2002). "Localization of the novel Xin protein to the adherens junction complex in cardiac and skeletal muscle during development". Dev Dyn. 225 (1): 1–13. doi:10.1002/dvdy.10131. PMID 12203715. S2CID 23393425.

[pmid15454575-7] Pacholsky D, Vakeel P, Himmel M, Lowe T, Stradal T, Rottner K, Furst DO, van der Ven PF (Oct 2004). "Xin repeats define a novel actin-binding motif". J Cell Sci. 117 (Pt 22): 5257–68. doi:10.1242/jcs.01406. PMID 15454575. S2CID 5643531.

[entrez-8] "Entrez Gene: CMYA3 cardiomyopathy associated 3".

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References

Further reading