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Young-Ki Paik

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Young-Ki Paik (Korean: 백영기) is the director of the Yonsei Proteome Research Center in Seoul, Korea. In 2009, he was chosen President of the Human Proteome Organization (HUPO).[1][2]

Education

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Paik grew up in Daejon City and Gangkyung city (Choong-Nam Province, until 6 years old), and Seoul, Korea, son of the High School Teacher Nam-Cheol Paik and hospital nurse Bok-Im Yu. He went to Yonsei University where majored in Biochemistry. After graduating in 1975, he was appointed as an army ROTC officer with second lieutenant of Korean Army and served Interpretation officer at the Korean Army Ordnance School till July 1977. After completing his military duty, he had a research position at Agency for Defense Development (ADD), where he was involved in the development of a civil defense kit of oxime drug that protects action of the AChE–nerve agent adduct.

Research and career

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In the summer of 1979, he went to the Graduate School of the University of Missouri in Columbia, Missouri where he majored in biochemistry with cholesterol biosynthesis enzymes under Jame L Gaylor, and received his Ph.D. in August 1983. Most of his work was done at Du Pont Company, Glenolden, PA, where his advisor (Dr. James L Gylor) moved to Du Pont in 1981. In 1983, he then moved to Gladstone Institutes, University of California, San Francisco, CA and started his postdoc carrier with John Taylor on molecular cell biology of human apolipoprotein E gene which is involved in transportation of cellular cholesterol from peripheral tissues to liver. The outcome of his postdoctoral studies was the molecular characterization and transcriptional regulation of human ApoE gene (ε4), which was later found to be involved in the late onset of Alzheimer disease.[3]

Pheromone discovery

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After completion of doctoral and post-doc training for 10 years in the US, he came back to Korea to set up his own research carrier in sterol metabolism at Hanyang University and Yonsei University. Most of work has been done at Yonsei University where he carried out three arms of research, sterol metabolism, C. elegans pheromone, and cancer proteomics.[4][5] While he works on the cholesterol metabolism at Yonsei University, his team was able to propose the 19 steps reaction pathway from lanosterol to cholesterol based on the position the sterol 24-reductase reaction which was cited by major BIOCHEMISTRY Textbooks (Voet and Voet). Later, he became very interested in C. elegans pheromone which was then not clearly identified yet. In 2005, he and his student, Pan-Young Jeong were able to identify dauer pheromone (now called ascaroside pheromone),[6] an important substance for chemical communication, developmental process and aging in C. elegans life history, for the first time and published this discovery in Nature. His discovery of pheromone not only opens up the field of chemical biology of pheromone research in this model animal but also has made important strides in our understanding of animal physiology under stressful environment where pheromone plays multiple roles.

Proteomics research

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While he works at the department of biochemistry, Yonsei University, he also became interested in proteomics, an emerging technology at that time. In 1999, Paik established Yonsei Proteome Research Center,[7] a flagship proteome center in Asia where he has carried out research on the human proteome,[8] aging[9] and cancer proteomics (liver and pancreatic cancers).[10][11] He contributed to development of international proteome societies, including Korean HUPO (KHUPO), AOHUPO and HUPO where he also served president.[12][13] In 2012, Paik and his colleagues at HUPO organized the international consortium of Chromosome-Centric Human Proteome Project (C-HPP) which aims to identify, quantify, and localize expression of at least one representative protein from each of the ~20,000 predicted protein-coding genes in a chromosome-by-chromosome manner.[14][15][16] The term ‘Missing Proteins’ was coined for the first time. During his term as chair of C-HPP consortium (2010-2018) which consists of 25 international teams, the C-HPP team laid out a long-term plan to characterize missingproteins and proteins of no known function (uPE1).

Awards and honors

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He received Kyung-Am Award, A Scientist of Month Award (Ministry of Science and Technology and Ministry of Health and Welfare),[17] DI Awards, MSD Awards and HUPO Distinguished Service Award. He was Director of Natural Science Division of the Korean Academy of Science and Technology.

Publications

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  • A molecular basis for reciprocal regulation between pheromones and hormones in response to dietary cues in C. Elegans.[19]
  • A novel functional cross-interaction between opioid and pheromone signaling may be involved in stress avoidance in Caenorhabditis elegans.[20]
  • Identification of ALDH6A1 as a Potential Molecular Signature in Hepatocellular Carcinoma via Quantitative Profiling of the Mitochondrial Proteome.[21]
  • Potential Regulatory Role of Human-Carboxylesterase-1 Glycosylation in Liver Cancer Cell Growth.[22]

References

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  1. ^ Y., K. Paik; J., E. Graham; M., Jones; F., McDonald; C., Holmes; V., Ozdemir (2009-11-30). "Interview with Dr. Young-Ki Paik, President of the Human Proteome Organization (HUPO): Pharmacoproteomics and the Approaching Wave of "Proteomics Diagnostics"". Current Pharmacogenomics and Personalized Medicine. 7 (4): 243–248. doi:10.2174/187569209790112292. S2CID 70687878.
  2. ^ "연세대학교 융합오믹스 의생명과학 협동과정". web.yonsei.ac.kr. Retrieved 2021-10-10.
  3. ^ Paik, Young-Ki; Chang, David J.; Reardon, Catherine A.; Davies, Glenn E.; Mahley, Robert W.; Taylor, John M. (1985). "Nucleotide Sequence and Structure of the Human Apolipoprotein E Gene". Proceedings of the National Academy of Sciences of the United States of America. 82 (10): 3445–3449. Bibcode:1985PNAS...82.3445P. doi:10.1073/pnas.82.10.3445. ISSN 0027-8424. JSTOR 25600. PMC 397792. PMID 2987927.
  4. ^ Cheong, Mi Cheong; Na, Keun; Kim, Heekyeong; Jeong, Seul-Ki; Joo, Hyoe-Jin; Chitwood, David J.; Paik, Young-Ki (2011-03-04). "A potential biochemical mechanism underlying the influence of sterol deprivation stress on Caenorhabditis elegans longevity". The Journal of Biological Chemistry. 286 (9): 7248–7256. doi:10.1074/jbc.M110.189183. ISSN 1083-351X. PMC 3044981. PMID 21186286.
  5. ^ "Young-Ki Paik on Proteomics in S. Korea and the Future of the Human Proteome Organization". Genomeweb. 2005-09-09. Retrieved 2021-10-10.
  6. ^ Park, Jun Young; Joo, Hyoe-Jin; Park, Saeram; Paik, Young-Ki (2019-08-09). "Ascaroside Pheromones: Chemical Biology and Pleiotropic Neuronal Functions". International Journal of Molecular Sciences. 20 (16): E3898. doi:10.3390/ijms20163898. ISSN 1422-0067. PMC 6719183. PMID 31405082.
  7. ^ "Yonsei Proteome Research Center 연세 프로테옴 연구원 단백체 분석". www.proteomix.org. Retrieved 2021-10-17.
  8. ^ Lee, Hyoung-Joo; Lee, Eun-Young; Kwon, Min-Seok; Paik, Young-Ki (February 2006). "Biomarker discovery from the plasma proteome using multidimensional fractionation proteomics". Current Opinion in Chemical Biology. 10 (1): 42–49. doi:10.1016/j.cbpa.2006.01.007. ISSN 1367-5931. PMID 16418010.
  9. ^ Hahm, Jeong-Hoon; Kim, Sunhee; Paik, Young-Ki (August 2009). "Endogenous cGMP regulates adult longevity via the insulin signaling pathway in Caenorhabditis elegans". Aging Cell. 8 (4): 473–483. doi:10.1111/j.1474-9726.2009.00495.x. ISSN 1474-9726. PMID 19489741. S2CID 593237.
  10. ^ Na, Keun; Jeong, Seul-Ki; Lee, Min Jung; Cho, Sang Yun; Kim, Sun A.; Lee, Min-Ji; Song, Si Young; Kim, Hoguen; Kim, Kyung Sik; Lee, Hyun Woong; Paik, Young-Ki (2013-07-15). "Human liver carboxylesterase 1 outperforms alpha-fetoprotein as biomarker to discriminate hepatocellular carcinoma from other liver diseases in Korean patients". International Journal of Cancer. 133 (2): 408–415. doi:10.1002/ijc.28020. ISSN 1097-0215. PMID 23319432. S2CID 22066885.
  11. ^ Shin, Heon; Cha, Hyun-Jeong; Na, Keun; Lee, Min Jung; Cho, Jin-Young; Kim, Chae-Yeon; Kim, Eun Kyung; Kang, Chang Moo; Kim, Hoguen; Paik, Young-Ki (2018-03-01). "O-GlcNAcylation of the Tumor Suppressor FOXO3 Triggers Aberrant Cancer Cell Growth". Cancer Research. 78 (5): 1214–1224. doi:10.1158/0008-5472.CAN-17-3512. ISSN 1538-7445. PMID 29301793. S2CID 5273650.
  12. ^ "AOHUPO - Asia Oceania Human Proteome Organisation". www.aohupo.org. Retrieved 2021-10-17.
  13. ^ "Young-Ki Paik on Proteomics in S. Korea and the Future of the Human Proteome Organization". Genomeweb. 2005-09-09. Retrieved 2021-10-17.
  14. ^ Paik, Young-Ki; Jeong, Seul-Ki; Omenn, Gilbert S.; Uhlen, Mathias; Hanash, Samir; Cho, Sang Yun; Lee, Hyoung-Joo; Na, Keun; Choi, Eun-Young; Yan, Fangfei; Zhang, Fan (March 2012). "The Chromosome-Centric Human Proteome Project for cataloging proteins encoded in the genome". Nature Biotechnology. 30 (3): 221–223. doi:10.1038/nbt.2152. ISSN 1546-1696. PMID 22398612. S2CID 205276763.
  15. ^ Paik, Young-Ki; Hancock, William S. (November 2012). "Uniting ENCODE with genome-wide proteomics". Nature Biotechnology. 30 (11): 1065–1067. doi:10.1038/nbt.2416. ISSN 1546-1696. PMID 23138303. S2CID 19627094.
  16. ^ Paik, Young-Ki; Omenn, Gilbert S.; Lane, Lydie; Overall, Christopher M. (December 2017). "Advances in the Chromosome-Centric Human Proteome Project: Looking to the Future". Expert Review of Proteomics. 14 (12): 1059–1071. doi:10.1080/14789450.2017.1394189. ISSN 1478-9450. PMC 6158320. PMID 29039980.
  17. ^ "이달의 과학기술인상". 이달의 과학기술인상 (in Korean). Retrieved 2021-10-17.
  18. ^ "lipid.or.kr".
  19. ^ Park, Saeram; Park, Jun Young; Paik, Young-Ki (2020). "A Molecular Basis for Reciprocal Regulation between Pheromones and Hormones in Response to Dietary Cues in C. elegans". International Journal of Molecular Sciences. 21 (7): 2366. doi:10.3390/ijms21072366. PMC 7177881. PMID 32235409.
  20. ^ Park, Jun Young; Cheong, Mi Cheong; Cho, Jin-Young; Koo, Hyeon-Sook; Paik, Young-Ki (2020-05-05). "A novel functional cross-interaction between opioid and pheromone signaling may be involved in stress avoidance in Caenorhabditis elegans". Scientific Reports. 10 (1): 7524. Bibcode:2020NatSR..10.7524P. doi:10.1038/s41598-020-64567-3. ISSN 2045-2322. PMC 7200713. PMID 32371913.
  21. ^ Shin, Heon; Cha, Hyun-Jeong; Lee, Min Jung; Na, Keun; Park, Donha; Kim, Chae-Yeon; Han, Dai Hoon; Kim, Hoguen; Paik, Young-Ki (2020-04-03). "Identification of ALDH6A1 as a Potential Molecular Signature in Hepatocellular Carcinoma via Quantitative Profiling of the Mitochondrial Proteome". Journal of Proteome Research. 19 (4): 1684–1695. doi:10.1021/acs.jproteome.9b00846. ISSN 1535-3907. PMID 31985234. S2CID 210923178.
  22. ^ Na, Keun; Kim, Minjoo; Kim, Chae-Yeon; Lim, Jong-Sun; Cho, Jin-Young; Shin, Heon; Lee, Hyo Jin; Kang, Byeong Jun; Han, Dai Hoon; Kim, Hoguen; Baik, Ja-Hyun (2020-12-04). "Potential Regulatory Role of Human-Carboxylesterase-1 Glycosylation in Liver Cancer Cell Growth". Journal of Proteome Research. 19 (12): 4867–4883. doi:10.1021/acs.jproteome.0c00787. ISSN 1535-3893. PMID 33206527. S2CID 227067526.
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