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ADAM19

From Wikipedia, the free encyclopedia
ADAM19
Identifiers
AliasesADAM19, MADDAM, MLTNB, FKSG34, ADAM metallopeptidase domain 19
External IDsOMIM: 603640; MGI: 105377; HomoloGene: 74925; GeneCards: ADAM19; OMA:ADAM19 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_023038
NM_033274

NM_001291890
NM_001291891
NM_009616
NM_001311209

RefSeq (protein)

NP_150377

NP_001278819
NP_001278820
NP_001298138
NP_033746

Location (UCSC)Chr 5: 157.4 – 157.58 MbChr 11: 45.95 – 46.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ADAM19 (A Disintegrin And Metalloproteinase 19, MADDAM, meltrin beta), is a human gene.[5]

Function

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This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has also been demonstrated to be an active metalloproteinase, which may be involved in normal physiological and pathological processes such as cells migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. Alternative splicing results in two transcript variants.[5]

Interactions

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ADAM19 has been shown to interact with ABI2.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135074Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000011256Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: ADAM19 ADAM metallopeptidase domain 19 (meltrin beta)".
  6. ^ Huang L, Feng L, Yang L, Zhou W, Zhao S, Li C (Sep 2002). "Screen and identification of proteins interacting with ADAM19 cytoplasmic tail". Molecular Biology Reports. 29 (3): 317–23. doi:10.1023/A:1020409217215. PMID 12463424. S2CID 22611084.
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Further reading

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