Jump to content

SNX4

From Wikipedia, the free encyclopedia
SNX4
Identifiers
AliasesSNX4, ATG24B, sorting nexin 4
External IDsOMIM: 605931; MGI: 1916400; HomoloGene: 36143; GeneCards: SNX4; OMA:SNX4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003794

NM_080557

RefSeq (protein)

NP_003785

NP_542124

Location (UCSC)Chr 3: 125.45 – 125.52 MbChr 16: 33.07 – 33.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sorting nexin-4 is a protein that in humans is encoded by the SNX4 gene.[5][6]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members.[6]

Interactions

[edit]

SNX4 has been shown to interact with BIN1.[7]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000114520Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022808Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Haft CR, de la Luz Sierra M, Barr VA, Haft DH, Taylor SI (Dec 1998). "Identification of a family of sorting nexin molecules and characterization of their association with receptors". Mol Cell Biol. 18 (12): 7278–87. doi:10.1128/mcb.18.12.7278. PMC 109309. PMID 9819414.
  6. ^ a b "Entrez Gene: SNX4 sorting nexin 4".
  7. ^ Leprince, Corinne; Le Scolan Erwan; Meunier Brigitte; Fraisier Vincent; Brandon Nathalie; De Gunzburg Jean; Camonis Jacques (May 2003). "Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking". J. Cell Sci. 116 (Pt 10). England: 1937–48. doi:10.1242/jcs.00403. ISSN 0021-9533. PMID 12668730.

Further reading

[edit]